Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

E. J. Corey; Teck Peng Loh; Sidduri AchyuthaRao; Donnette C. Daley; Sepehr Sarshar

doi:10.1021/jo00073a013

Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

E. J. Corey^*, Teck Peng Loh, Sidduri AchyuthaRao, Donnette C. Daley, Sepehr Sarshar

^*Corresponding author for this work

Harvard University

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.

Original language	English
Pages (from-to)	5600-5602
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	58
Issue number	21
DOIs	https://doi.org/10.1021/jo00073a013
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus Subject Areas

Organic Chemistry

Access to Document

10.1021/jo00073a013

Cite this

@article{f1b90ebb10bf4f868ed57bf0f737e100,

title = "Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine",

abstract = "The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.",

author = "Corey, {E. J.} and Loh, {Teck Peng} and Sidduri AchyuthaRao and Daley, {Donnette C.} and Sepehr Sarshar",

year = "1993",

doi = "10.1021/jo00073a013",

language = "English",

volume = "58",

pages = "5600--5602",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "21",

}

TY - JOUR

T1 - Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

AU - Corey, E. J.

AU - Loh, Teck Peng

AU - AchyuthaRao, Sidduri

AU - Daley, Donnette C.

AU - Sarshar, Sepehr

PY - 1993

Y1 - 1993

N2 - The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.

AB - The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.

UR - http://www.scopus.com/inward/record.url?scp=0027442712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027442712&partnerID=8YFLogxK

U2 - 10.1021/jo00073a013

DO - 10.1021/jo00073a013

M3 - Article

AN - SCOPUS:0027442712

SN - 0022-3263

VL - 58

SP - 5600

EP - 5602

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 21

ER -

Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

Abstract

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this