Structure of a conserved golgi complex-targeting signal in coronavirus envelope proteins

Yan Li; Wahyu Surya; Stephanie Claudine; Jaume Torres

doi:10.1074/jbc.M114.560094

Structure of a conserved golgi complex-targeting signal in coronavirus envelope proteins

Yan Li, Wahyu Surya, Stephanie Claudine, Jaume Torres^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Background: Coronavirus envelope (CoV E) proteins have a predicted β-coil-γ motif reported to target the Golgi complex. Results: This conserved domain forms α-structure on its own but is α-helical in the context of full-length SARS-CoV E protein. Conclusion: This domain is potentially involved in large conformational transitions. Significance: This is the first structural data of the extramembrane domain of any coronavirus E protein.

Original language	English
Pages (from-to)	12535-12549
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M114.560094
Publication status	Published - 2014
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.560094

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abstract = "Background: Coronavirus envelope (CoV E) proteins have a predicted β-coil-γ motif reported to target the Golgi complex. Results: This conserved domain forms α-structure on its own but is α-helical in the context of full-length SARS-CoV E protein. Conclusion: This domain is potentially involved in large conformational transitions. Significance: This is the first structural data of the extramembrane domain of any coronavirus E protein.",

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AU - Claudine, Stephanie

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AB - Background: Coronavirus envelope (CoV E) proteins have a predicted β-coil-γ motif reported to target the Golgi complex. Results: This conserved domain forms α-structure on its own but is α-helical in the context of full-length SARS-CoV E protein. Conclusion: This domain is potentially involved in large conformational transitions. Significance: This is the first structural data of the extramembrane domain of any coronavirus E protein.

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Structure of a conserved golgi complex-targeting signal in coronavirus envelope proteins

Abstract

ASJC Scopus Subject Areas

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