Studies on the synthesis of the lasubine alkaloids

Nur Filza bte Mohamed Aslam; Oliver Simon; Roderick W. Bates

doi:10.1016/j.tet.2018.06.031

Studies on the synthesis of the lasubine alkaloids

Nur Filza bte Mohamed Aslam, Oliver Simon, Roderick W. Bates^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine.

Original language	English
Pages (from-to)	5032-5039
Number of pages	8
Journal	Tetrahedron
Volume	74
Issue number	38
DOIs	https://doi.org/10.1016/j.tet.2018.06.031
Publication status	Published - Sept 20 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Alkaloid
Allylation
Indolizidine
Isoxazolidine
Tandem

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10.1016/j.tet.2018.06.031

Cite this

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title = "Studies on the synthesis of the lasubine alkaloids",

abstract = "Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine.",

keywords = "Alkaloid, Allylation, Indolizidine, Isoxazolidine, Tandem",

author = "{Mohamed Aslam}, {Nur Filza bte} and Oliver Simon and Bates, {Roderick W.}",

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year = "2018",

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AU - Mohamed Aslam, Nur Filza bte

AU - Simon, Oliver

AU - Bates, Roderick W.

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N2 - Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine.

AB - Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine.

KW - Alkaloid

KW - Allylation

KW - Indolizidine

KW - Isoxazolidine

KW - Tandem

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DO - 10.1016/j.tet.2018.06.031

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ER -

Studies on the synthesis of the lasubine alkaloids

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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