TY - JOUR
T1 - Surface characteristics and antimicrobial properties of modified catheter surfaces by polypyrogallol and metal ions
AU - Balne, Praveen Kumar
AU - Harini, Sriram
AU - Dhand, Chetna
AU - Dwivedi, Neeraj
AU - Chalasani, Madhavi Latha Somaraju
AU - Verma, Navin Kumar
AU - Barathi, Veluchamy Amutha
AU - Beuerman, Roger
AU - Agrawal, Rupesh
AU - Lakshminarayanan, Rajamani
N1 - Publisher Copyright:
© 2018
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Catheter associated infections (CAIs) are the major cause of nosocomial infections leading to increased morbidity, mortality rates and economical loss. Though the antibiotic coated surface modified catheters are reported to be effective in preventing CAIs, presence of sub-lethal concentrations of antibiotics in long term instilled catheters poses a risk of development and spread of drug resistant microbial strains. Herein, we have developed an antibiotic-free alternative strategy to coat catheter surfaces using pyrogallol (PG) and metal ions (Ag+/Mg2+). Surface characteristics, antimicrobial and anti-biofilm properties with hemocompatibility of the coated catheters were studied. Structural characteristics of coated catheters were similar to the uncoated catheters with improved wettability. All the coated catheters with PG and different PG/metal ion combinations exhibited broad spectrum antibacterial activity. Catheters coated with PG/metal ions combination showed effective antibiofilm properties against MRSA strains. None of the coated catheters showed any significant hemolysis for rabbit erythrocytes. In addition, polypyrogallol (pPG) coating attenuated the hemolytic properties of silver without altering the antimicrobial properties. The inherent antimicrobial properties of the coating agent along with antimicrobial metal ions broaden the application landscape which includes coating of other medical devices, clean room construction and development of antimicrobial surfaces. The chemical formulation can also be used to design antiseptic solutions to prevent healthcare associated infections.
AB - Catheter associated infections (CAIs) are the major cause of nosocomial infections leading to increased morbidity, mortality rates and economical loss. Though the antibiotic coated surface modified catheters are reported to be effective in preventing CAIs, presence of sub-lethal concentrations of antibiotics in long term instilled catheters poses a risk of development and spread of drug resistant microbial strains. Herein, we have developed an antibiotic-free alternative strategy to coat catheter surfaces using pyrogallol (PG) and metal ions (Ag+/Mg2+). Surface characteristics, antimicrobial and anti-biofilm properties with hemocompatibility of the coated catheters were studied. Structural characteristics of coated catheters were similar to the uncoated catheters with improved wettability. All the coated catheters with PG and different PG/metal ion combinations exhibited broad spectrum antibacterial activity. Catheters coated with PG/metal ions combination showed effective antibiofilm properties against MRSA strains. None of the coated catheters showed any significant hemolysis for rabbit erythrocytes. In addition, polypyrogallol (pPG) coating attenuated the hemolytic properties of silver without altering the antimicrobial properties. The inherent antimicrobial properties of the coating agent along with antimicrobial metal ions broaden the application landscape which includes coating of other medical devices, clean room construction and development of antimicrobial surfaces. The chemical formulation can also be used to design antiseptic solutions to prevent healthcare associated infections.
KW - Antimicrobial
KW - Broad-spectrum
KW - Catheter coating
KW - Metal ions
KW - Non-hemolytic
KW - Pyrogallol
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U2 - 10.1016/j.msec.2018.04.095
DO - 10.1016/j.msec.2018.04.095
M3 - Article
C2 - 29853139
AN - SCOPUS:85046832885
SN - 0928-4931
VL - 90
SP - 673
EP - 684
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -