Abstract
The biomarkers of many diseases such as malaria can be found in intradermal measurements. We will present two surface enhanced Raman spectroscopy (SERS) based methods for the detection of malaria biomarkers in blood, which are comparable to or outperform the standard clinical method. To eliminate the need of drawing blood, we will also report a stainless-steel microneedle based probe for direct intradermal SERS measurements. Moreover, we developed a deformable agarose needle to reduce the risk of sharp injury and cross contamination due to needle reuse. Tests in skin phantoms for glucose measurements demonstrated accuracy comparable to those traditional methods requiring blood drawing.
| Original language | English |
|---|---|
| Title of host publication | Plasmonics in Biology and Medicine XV |
| Editors | Joseph R. Lakowicz, Tuan Vo-Dinh |
| Publisher | SPIE |
| ISBN (Electronic) | 9781510615038 |
| DOIs | |
| Publication status | Published - 2018 |
| Externally published | Yes |
| Event | Plasmonics in Biology and Medicine XV 2017 - San Francisco, United States Duration: Jan 29 2017 → Jan 29 2017 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 10509 |
| ISSN (Print) | 1605-7422 |
Conference
| Conference | Plasmonics in Biology and Medicine XV 2017 |
|---|---|
| Country/Territory | United States |
| City | San Francisco |
| Period | 1/29/17 → 1/29/17 |
Bibliographical note
Publisher Copyright:© 2018 SPIE.
ASJC Scopus Subject Areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomaterials
- Radiology Nuclear Medicine and imaging
Keywords
- agarose
- hemozoin
- intradermal measurements
- malaria
- microneedle
- Raman
- silver
- surface enhanced Raman scattering (SERS)
