Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device

Yuwei Zhang; Ayden Malekjahani; Buddhisha N. Udugama; Pranav Kadhiresan; Hongmin Chen; Matthew Osborne; Max Franz; Mike Kucera; Simon Plenderleith; Lily Yip; Gary D. Bader; Vanessa Tran; Jonathan B. Gubbay; Allison McGeer; Samira Mubareka; Warren C.W. Chan

doi:10.1021/acs.nanolett.1c01280

Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device

Yuwei Zhang, Ayden Malekjahani, Buddhisha N. Udugama, Pranav Kadhiresan, Hongmin Chen, Matthew Osborne, Max Franz, Mike Kucera, Simon Plenderleith, Lily Yip, Gary D. Bader, Vanessa Tran, Jonathan B. Gubbay, Allison McGeer, Samira Mubareka, Warren C.W. Chan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, as compared to 34% and 100%, respectively, for lateral flow assays in a head-to-head comparison. The lateral flow assay misdiagnosed μ2 out of 3 SARS-CoV-2 positive patients. Our quantum dot barcode device has μ3 times greater clinical sensitivity because it is μ140 times more analytically sensitive than lateral flow assays. Our device can diagnose SARS-CoV-2 at different sampling dates and infectious severity. We developed a databasing app to provide instantaneous results to inform patients, physicians, and public health agencies. This assay and device enable real-time surveillance of SARS-CoV-2 seroprevalence and potential immunity.

Original language	English
Pages (from-to)	5209-5216
Number of pages	8
Journal	Nano Letters
Volume	21
Issue number	12
DOIs	https://doi.org/10.1021/acs.nanolett.1c01280
Publication status	Published - Jun 23 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society.

ASJC Scopus Subject Areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Keywords

COVID-19
database
immunoassay
multiplexing
quantum dot barcodes
real-time monitoring
SARS-CoV-2
serological testing
smartphone diagnostics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acs.nanolett.1c01280

Cite this

Zhang, Y., Malekjahani, A., Udugama, B. N., Kadhiresan, P., Chen, H., Osborne, M., Franz, M., Kucera, M., Plenderleith, S., Yip, L., Bader, G. D., Tran, V., Gubbay, J. B., McGeer, A., Mubareka, S., & Chan, W. C. W. (2021). Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device. Nano Letters, 21(12), 5209-5216. https://doi.org/10.1021/acs.nanolett.1c01280

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abstract = "The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, as compared to 34% and 100%, respectively, for lateral flow assays in a head-to-head comparison. The lateral flow assay misdiagnosed μ2 out of 3 SARS-CoV-2 positive patients. Our quantum dot barcode device has μ3 times greater clinical sensitivity because it is μ140 times more analytically sensitive than lateral flow assays. Our device can diagnose SARS-CoV-2 at different sampling dates and infectious severity. We developed a databasing app to provide instantaneous results to inform patients, physicians, and public health agencies. This assay and device enable real-time surveillance of SARS-CoV-2 seroprevalence and potential immunity.",

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author = "Yuwei Zhang and Ayden Malekjahani and Udugama, {Buddhisha N.} and Pranav Kadhiresan and Hongmin Chen and Matthew Osborne and Max Franz and Mike Kucera and Simon Plenderleith and Lily Yip and Bader, {Gary D.} and Vanessa Tran and Gubbay, {Jonathan B.} and Allison McGeer and Samira Mubareka and Chan, {Warren C.W.}",

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Zhang, Y, Malekjahani, A, Udugama, BN, Kadhiresan, P, Chen, H, Osborne, M, Franz, M, Kucera, M, Plenderleith, S, Yip, L, Bader, GD, Tran, V, Gubbay, JB, McGeer, A, Mubareka, S & Chan, WCW 2021, 'Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device', Nano Letters, vol. 21, no. 12, pp. 5209-5216. https://doi.org/10.1021/acs.nanolett.1c01280

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AU - Zhang, Yuwei

AU - Malekjahani, Ayden

AU - Udugama, Buddhisha N.

AU - Kadhiresan, Pranav

AU - Chen, Hongmin

AU - Osborne, Matthew

AU - Franz, Max

AU - Kucera, Mike

AU - Plenderleith, Simon

AU - Yip, Lily

AU - Bader, Gary D.

AU - Tran, Vanessa

AU - Gubbay, Jonathan B.

AU - McGeer, Allison

AU - Mubareka, Samira

AU - Chan, Warren C.W.

PY - 2021/6/23

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N2 - The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, as compared to 34% and 100%, respectively, for lateral flow assays in a head-to-head comparison. The lateral flow assay misdiagnosed μ2 out of 3 SARS-CoV-2 positive patients. Our quantum dot barcode device has μ3 times greater clinical sensitivity because it is μ140 times more analytically sensitive than lateral flow assays. Our device can diagnose SARS-CoV-2 at different sampling dates and infectious severity. We developed a databasing app to provide instantaneous results to inform patients, physicians, and public health agencies. This assay and device enable real-time surveillance of SARS-CoV-2 seroprevalence and potential immunity.

AB - The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, as compared to 34% and 100%, respectively, for lateral flow assays in a head-to-head comparison. The lateral flow assay misdiagnosed μ2 out of 3 SARS-CoV-2 positive patients. Our quantum dot barcode device has μ3 times greater clinical sensitivity because it is μ140 times more analytically sensitive than lateral flow assays. Our device can diagnose SARS-CoV-2 at different sampling dates and infectious severity. We developed a databasing app to provide instantaneous results to inform patients, physicians, and public health agencies. This assay and device enable real-time surveillance of SARS-CoV-2 seroprevalence and potential immunity.

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KW - immunoassay

KW - multiplexing

KW - quantum dot barcodes

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Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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Cite this