Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription

Bee Yen Teo; Nguan Soon Tan; Toong Jin Lam; Jeak Ling Ding

doi:10.1016/S0014-5793(99)01212-0

Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription

Bee Yen Teo, Nguan Soon Tan, Toong Jin Lam, Jeak Ling Ding^*

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The Oreochromis aureus vitellogenin (OaVtg) gene contains three imperfect oestrogen response elements (EREs) and GATA and VBP (vitellogenin binding protein) binding sites. An analysis of the promoter indicates that the 5'-flanking region up to position -625 is sufficient to mediate E₂ control. Furthermore, transfection of deletion and mutagenised promoters indicates that both GATA and VBP synergise with ER, and thus contribute to the regulation of the endogenous OaVtg gene. These findings support the notion that the interplay of promoter elements mediates proper hormone-dependent and tissue-specific expression of the OaVtg gene, regardless of non-consensus sequence context of EREs and VBP. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	57-63
Number of pages	7
Journal	FEBS Letters
Volume	459
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(99)01212-0
Publication status	Published - Oct 1 1999
Externally published	Yes

ASJC Scopus Subject Areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Keywords

Estrogen receptor
GATA
Imperfect estrogen response element
Oreochromis aureus
Vitellogenin binding protein
Vitellogenin gene promoter

Access to Document

10.1016/S0014-5793(99)01212-0

Cite this

@article{d2bc072bea2340359b87e91e05046885,

title = "Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription",

abstract = "The Oreochromis aureus vitellogenin (OaVtg) gene contains three imperfect oestrogen response elements (EREs) and GATA and VBP (vitellogenin binding protein) binding sites. An analysis of the promoter indicates that the 5'-flanking region up to position -625 is sufficient to mediate E2 control. Furthermore, transfection of deletion and mutagenised promoters indicates that both GATA and VBP synergise with ER, and thus contribute to the regulation of the endogenous OaVtg gene. These findings support the notion that the interplay of promoter elements mediates proper hormone-dependent and tissue-specific expression of the OaVtg gene, regardless of non-consensus sequence context of EREs and VBP. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "Estrogen receptor, GATA, Imperfect estrogen response element, Oreochromis aureus, Vitellogenin binding protein, Vitellogenin gene promoter",

author = "Teo, {Bee Yen} and Tan, {Nguan Soon} and Lam, {Toong Jin} and Ding, {Jeak Ling}",

year = "1999",

month = oct,

day = "1",

doi = "10.1016/S0014-5793(99)01212-0",

language = "English",

volume = "459",

pages = "57--63",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription

AU - Teo, Bee Yen

AU - Tan, Nguan Soon

AU - Lam, Toong Jin

AU - Ding, Jeak Ling

PY - 1999/10/1

Y1 - 1999/10/1

N2 - The Oreochromis aureus vitellogenin (OaVtg) gene contains three imperfect oestrogen response elements (EREs) and GATA and VBP (vitellogenin binding protein) binding sites. An analysis of the promoter indicates that the 5'-flanking region up to position -625 is sufficient to mediate E2 control. Furthermore, transfection of deletion and mutagenised promoters indicates that both GATA and VBP synergise with ER, and thus contribute to the regulation of the endogenous OaVtg gene. These findings support the notion that the interplay of promoter elements mediates proper hormone-dependent and tissue-specific expression of the OaVtg gene, regardless of non-consensus sequence context of EREs and VBP. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - The Oreochromis aureus vitellogenin (OaVtg) gene contains three imperfect oestrogen response elements (EREs) and GATA and VBP (vitellogenin binding protein) binding sites. An analysis of the promoter indicates that the 5'-flanking region up to position -625 is sufficient to mediate E2 control. Furthermore, transfection of deletion and mutagenised promoters indicates that both GATA and VBP synergise with ER, and thus contribute to the regulation of the endogenous OaVtg gene. These findings support the notion that the interplay of promoter elements mediates proper hormone-dependent and tissue-specific expression of the OaVtg gene, regardless of non-consensus sequence context of EREs and VBP. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - Estrogen receptor

KW - GATA

KW - Imperfect estrogen response element

KW - Oreochromis aureus

KW - Vitellogenin binding protein

KW - Vitellogenin gene promoter

UR - http://www.scopus.com/inward/record.url?scp=0032832679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032832679&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(99)01212-0

DO - 10.1016/S0014-5793(99)01212-0

M3 - Article

C2 - 10508917

AN - SCOPUS:0032832679

SN - 0014-5793

VL - 459

SP - 57

EP - 63

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this