Synthesis and characterization of neodymium(III) and gadolinium(III)-substituted hydroxyapatite as biomaterials

Yan Li; Chui Ping Ooi; Philip Cheang Hong Ning; Khiam Aik Khor

doi:10.1111/j.1744-7402.2008.02293.x

Synthesis and characterization of neodymium(III) and gadolinium(III)-substituted hydroxyapatite as biomaterials

Yan Li, Chui Ping Ooi^*, Philip Cheang Hong Ning, Khiam Aik Khor

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Nanocrystalline hydroxyapatite (HA), Ca₁₀ (PO₄)₆(OH)₂, substituted with gadolinium(III)(Gd³⁺) and neodymium(III) (Nd³⁺) in different mole ratios (M_added/Ca_added = X M, 0.01, 0.05, 0.1, and 0.2), was synthesized by an ion-exchange method. All samples had the single phase of HA except for X_M =0.2, which displayed the second phase of M(OH)₃. All were B-type carbonated HA. The nanoparticles were elongated spheroids of around 70nm, and the shape and size did not change significantly with an increase of X_M. The M(III)-doped HA had higher electrical conductivity compared with pure HA. A cytotoxicity test showed all were noncytotoxic except for X_Gd = 0.2.

Original language	English
Pages (from-to)	501-512
Number of pages	12
Journal	International Journal of Applied Ceramic Technology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1111/j.1744-7402.2008.02293.x
Publication status	Published - 2009
Externally published	Yes

ASJC Scopus Subject Areas

Ceramics and Composites
Condensed Matter Physics
Marketing
Materials Chemistry

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title = "Synthesis and characterization of neodymium(III) and gadolinium(III)-substituted hydroxyapatite as biomaterials",

abstract = "Nanocrystalline hydroxyapatite (HA), Ca10 (PO4)6(OH)2, substituted with gadolinium(III)(Gd3+) and neodymium(III) (Nd3+) in different mole ratios (Madded/Caadded = X M, 0.01, 0.05, 0.1, and 0.2), was synthesized by an ion-exchange method. All samples had the single phase of HA except for XM =0.2, which displayed the second phase of M(OH)3. All were B-type carbonated HA. The nanoparticles were elongated spheroids of around 70nm, and the shape and size did not change significantly with an increase of XM. The M(III)-doped HA had higher electrical conductivity compared with pure HA. A cytotoxicity test showed all were noncytotoxic except for XGd = 0.2.",

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AU - Li, Yan

AU - Ooi, Chui Ping

AU - Cheang Hong Ning, Philip

AU - Aik Khor, Khiam

PY - 2009

Y1 - 2009

N2 - Nanocrystalline hydroxyapatite (HA), Ca10 (PO4)6(OH)2, substituted with gadolinium(III)(Gd3+) and neodymium(III) (Nd3+) in different mole ratios (Madded/Caadded = X M, 0.01, 0.05, 0.1, and 0.2), was synthesized by an ion-exchange method. All samples had the single phase of HA except for XM =0.2, which displayed the second phase of M(OH)3. All were B-type carbonated HA. The nanoparticles were elongated spheroids of around 70nm, and the shape and size did not change significantly with an increase of XM. The M(III)-doped HA had higher electrical conductivity compared with pure HA. A cytotoxicity test showed all were noncytotoxic except for XGd = 0.2.

AB - Nanocrystalline hydroxyapatite (HA), Ca10 (PO4)6(OH)2, substituted with gadolinium(III)(Gd3+) and neodymium(III) (Nd3+) in different mole ratios (Madded/Caadded = X M, 0.01, 0.05, 0.1, and 0.2), was synthesized by an ion-exchange method. All samples had the single phase of HA except for XM =0.2, which displayed the second phase of M(OH)3. All were B-type carbonated HA. The nanoparticles were elongated spheroids of around 70nm, and the shape and size did not change significantly with an increase of XM. The M(III)-doped HA had higher electrical conductivity compared with pure HA. A cytotoxicity test showed all were noncytotoxic except for XGd = 0.2.

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Synthesis and characterization of neodymium(III) and gadolinium(III)-substituted hydroxyapatite as biomaterials

Abstract

ASJC Scopus Subject Areas

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