Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

Bing Zhi Chen; Man Ling Zhi; Chuang Xin Wang; Xue Qiang Chu; Zhi Liang Shen; Teck Peng Loh

doi:10.1021/acs.orglett.8b00441

Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

Bing Zhi Chen, Man Ling Zhi, Chuang Xin Wang, Xue Qiang Chu, Zhi Liang Shen^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.

Original language	English
Pages (from-to)	1902-1905
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	7
DOIs	https://doi.org/10.1021/acs.orglett.8b00441
Publication status	Published - Apr 6 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/acs.orglett.8b00441

Cite this

@article{f4407430079c46d283a7f941240d0d83,

title = "Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides",

abstract = "An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.",

author = "Chen, \{Bing Zhi\} and Zhi, \{Man Ling\} and Wang, \{Chuang Xin\} and Chu, \{Xue Qiang\} and Shen, \{Zhi Liang\} and Loh, \{Teck Peng\}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = apr,

day = "6",

doi = "10.1021/acs.orglett.8b00441",

language = "English",

volume = "20",

pages = "1902--1905",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

AU - Chen, Bing Zhi

AU - Zhi, Man Ling

AU - Wang, Chuang Xin

AU - Chu, Xue Qiang

AU - Shen, Zhi Liang

AU - Loh, Teck Peng

PY - 2018/4/6

Y1 - 2018/4/6

N2 - An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.

AB - An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.

UR - http://www.scopus.com/inward/record.url?scp=85045153155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045153155&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.8b00441

DO - 10.1021/acs.orglett.8b00441

M3 - Article

C2 - 29527900

AN - SCOPUS:85045153155

SN - 1523-7060

VL - 20

SP - 1902

EP - 1905

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this