Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

Natarajan Srikanth; Choon Hong Tan; Siu Choon Ng; Teck Peng Loh; Lip Lin Koh; Keng Yeow Sim

doi:10.1039/a701410d

Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

Natarajan Srikanth, Choon Hong Tan, Siu Choon Ng, Teck Peng Loh, Lip Lin Koh, Keng Yeow Sim^*

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.

Original language	English
Pages (from-to)	274-275
Number of pages	2
Journal	Journal of Chemical Research - Part S
Issue number	8
DOIs	https://doi.org/10.1039/a701410d
Publication status	Published - 1997
Externally published	Yes

ASJC Scopus Subject Areas

General Chemistry

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title = "Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens",

abstract = "The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.",

author = "Natarajan Srikanth and Tan, \{Choon Hong\} and Ng, \{Siu Choon\} and Loh, \{Teck Peng\} and Koh, \{Lip Lin\} and Sim, \{Keng Yeow\}",

year = "1997",

doi = "10.1039/a701410d",

language = "English",

pages = "274--275",

journal = "Journal of Chemical Research - Part S",

issn = "0308-2342",

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T1 - Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

AU - Srikanth, Natarajan

AU - Tan, Choon Hong

AU - Ng, Siu Choon

AU - Loh, Teck Peng

AU - Koh, Lip Lin

AU - Sim, Keng Yeow

PY - 1997

Y1 - 1997

N2 - The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.

AB - The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.

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JO - Journal of Chemical Research - Part S

JF - Journal of Chemical Research - Part S

IS - 8

ER -

Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

Abstract

ASJC Scopus Subject Areas

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