Synthesis of high surface area mesostructured calcium phosphate particles

Suxiu Ng; Jun Guo; Jan Ma; Say Chye Joachim Loo

doi:10.1016/j.actbio.2010.03.017

Synthesis of high surface area mesostructured calcium phosphate particles

Suxiu Ng, Jun Guo, Jan Ma, Say Chye Joachim Loo

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

High surface area mesostructured calcium phosphate (MCP) particles were synthesized using surfactants (F127 and P123) and the textural properties were optimized in this study. The synthesized MCP samples subsequently underwent surfactant washing for surfactant removal, which achieved surface areas of >200 m²g^-1. It was found that both F127 and P123 gave similar surface areas (S_Bet), but differing pore diameters (D _pore). Other synthesis parameters, such as synthesis temperature, surfactant concentration and pH, were also studied to further optimize the textural properties of MCP. It was found that the highest surface area MCP was synthesized at 25°C and pH 12, with 80 wt.% surfactant concentration. Further, in vitro loading and delivery tests on optimized MCP showed an enhanced loading efficiency of bovine serum albumin and lysozyme as compared with non-mesostructured calcium phosphate.

Original language	English
Pages (from-to)	3772-3781
Number of pages	10
Journal	Acta Biomaterialia
Volume	6
Issue number	9
DOIs	https://doi.org/10.1016/j.actbio.2010.03.017
Publication status	Published - Sept 2010
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Biology

Keywords

Controlled drug delivery
Mesoporous
Non-ionic surfactants
Pore size
Surfactant washing

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10.1016/j.actbio.2010.03.017

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title = "Synthesis of high surface area mesostructured calcium phosphate particles",

abstract = "High surface area mesostructured calcium phosphate (MCP) particles were synthesized using surfactants (F127 and P123) and the textural properties were optimized in this study. The synthesized MCP samples subsequently underwent surfactant washing for surfactant removal, which achieved surface areas of >200 m2g-1. It was found that both F127 and P123 gave similar surface areas (SBet), but differing pore diameters (D pore). Other synthesis parameters, such as synthesis temperature, surfactant concentration and pH, were also studied to further optimize the textural properties of MCP. It was found that the highest surface area MCP was synthesized at 25°C and pH 12, with 80 wt.\% surfactant concentration. Further, in vitro loading and delivery tests on optimized MCP showed an enhanced loading efficiency of bovine serum albumin and lysozyme as compared with non-mesostructured calcium phosphate.",

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author = "Suxiu Ng and Jun Guo and Jan Ma and Loo, \{Say Chye Joachim\}",

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AU - Ng, Suxiu

AU - Guo, Jun

AU - Ma, Jan

AU - Loo, Say Chye Joachim

PY - 2010/9

Y1 - 2010/9

N2 - High surface area mesostructured calcium phosphate (MCP) particles were synthesized using surfactants (F127 and P123) and the textural properties were optimized in this study. The synthesized MCP samples subsequently underwent surfactant washing for surfactant removal, which achieved surface areas of >200 m2g-1. It was found that both F127 and P123 gave similar surface areas (SBet), but differing pore diameters (D pore). Other synthesis parameters, such as synthesis temperature, surfactant concentration and pH, were also studied to further optimize the textural properties of MCP. It was found that the highest surface area MCP was synthesized at 25°C and pH 12, with 80 wt.% surfactant concentration. Further, in vitro loading and delivery tests on optimized MCP showed an enhanced loading efficiency of bovine serum albumin and lysozyme as compared with non-mesostructured calcium phosphate.

AB - High surface area mesostructured calcium phosphate (MCP) particles were synthesized using surfactants (F127 and P123) and the textural properties were optimized in this study. The synthesized MCP samples subsequently underwent surfactant washing for surfactant removal, which achieved surface areas of >200 m2g-1. It was found that both F127 and P123 gave similar surface areas (SBet), but differing pore diameters (D pore). Other synthesis parameters, such as synthesis temperature, surfactant concentration and pH, were also studied to further optimize the textural properties of MCP. It was found that the highest surface area MCP was synthesized at 25°C and pH 12, with 80 wt.% surfactant concentration. Further, in vitro loading and delivery tests on optimized MCP showed an enhanced loading efficiency of bovine serum albumin and lysozyme as compared with non-mesostructured calcium phosphate.

KW - Controlled drug delivery

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KW - Non-ionic surfactants

KW - Pore size

KW - Surfactant washing

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Synthesis of high surface area mesostructured calcium phosphate particles

Abstract

ASJC Scopus Subject Areas

Keywords

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