Synthesis of isoquinolines from α-aryl vinyl azides and internal alkynes by Rh-Cu bimetallic cooperation

Yi Feng Wang; Kah Kah Toh; Jian Yuan Lee; Shunsuke Chiba

doi:10.1002/anie.201101009

Synthesis of isoquinolines from α-aryl vinyl azides and internal alkynes by Rh-Cu bimetallic cooperation

Yi Feng Wang, Kah Kah Toh, Jian Yuan Lee, Shunsuke Chiba^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

287 Citations (Scopus)

Abstract

Catalysts in a relay: A synthetic method for delivering highly substituted isoquinolines has been developed (see scheme; Cp =C₅Me₅, DMF=N,N-dimethylformamide, TEMPO=2,2,6,6-tetramethylpiperidine-1-oxyl). A preliminary mechanistic study showed that the rhodium and copper cooperate synergistically in the multistep sequence.

Original language	English
Pages (from-to)	5927-5931
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	26
DOIs	https://doi.org/10.1002/anie.201101009
Publication status	Published - Jun 20 2011
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Keywords

alkynes
azides
copper
heterocycles
rhodium

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10.1002/anie.201101009

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AU - Chiba, Shunsuke

PY - 2011/6/20

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AB - Catalysts in a relay: A synthetic method for delivering highly substituted isoquinolines has been developed (see scheme; Cp =C5Me5, DMF=N,N-dimethylformamide, TEMPO=2,2,6,6-tetramethylpiperidine-1-oxyl). A preliminary mechanistic study showed that the rhodium and copper cooperate synergistically in the multistep sequence.

KW - alkynes

KW - azides

KW - copper

KW - heterocycles

KW - rhodium

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Synthesis of isoquinolines from α-aryl vinyl azides and internal alkynes by Rh-Cu bimetallic cooperation

Abstract

ASJC Scopus Subject Areas

Keywords

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