Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant

Yun He Xu; Tao He; Qiu Chi Zhang; Teck Peng Loh

doi:10.1039/c3cc49683j

Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)₂ with molecular oxygen as an oxidant

Yun He Xu^*, Tao He, Qiu Chi Zhang, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

A cyclization reaction between enamides and alkynes catalyzed by palladium(ii) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.

Original language	English
Pages (from-to)	2784-2786
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	21
DOIs	https://doi.org/10.1039/c3cc49683j
Publication status	Published - Feb 13 2014
Externally published	Yes

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "A cyclization reaction between enamides and alkynes catalyzed by palladium(ii) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.",

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AU - Xu, Yun He

AU - He, Tao

AU - Zhang, Qiu Chi

AU - Loh, Teck Peng

PY - 2014/2/13

Y1 - 2014/2/13

N2 - A cyclization reaction between enamides and alkynes catalyzed by palladium(ii) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.

AB - A cyclization reaction between enamides and alkynes catalyzed by palladium(ii) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.

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ER -

Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)₂ with molecular oxygen as an oxidant

Abstract

ASJC Scopus Subject Areas

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