Synthesis of nano-capsules via aqueous emulsion RCMP-PISA and encapsulation

Jit Sarkar; Alexander W. Jackson; Alexander M. Van Herk; Atsushi Goto

doi:10.1039/d0py00465k

Synthesis of nano-capsules via aqueous emulsion RCMP-PISA and encapsulation

Jit Sarkar, Alexander W. Jackson, Alexander M. Van Herk^*, Atsushi Goto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Biocompatible nano-capsules (polymer vesicles) were prepared by combining NaI-catalyzed living radical polymerization with aqueous emulsion PISA (polymerization induced self-assembly). Poly(ethylene glycol) methyl ether methacrylate (PEGMA) and methyl methacrylate (MMA) were used as hydrophilic and hydrophobic monomers, respectively. Spheres and vesicles were generated depending on the degrees of polymerization of the hydrophilic and hydrophobic segments in the block copolymers. The spheres and vesicles were crosslinked using a divinyl monomer (ethylene glycol dimethacrylate (EGDMA)) as a co-monomer of MMA in situ during the polymerization. The encapsulation ability of the obtained vesicle was studied using a hydrophilic dye, i.e., rhodamine-B.

Original language	English
Pages (from-to)	3904-3912
Number of pages	9
Journal	Polymer Chemistry
Volume	11
Issue number	23
DOIs	https://doi.org/10.1039/d0py00465k
Publication status	Published - Jun 21 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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title = "Synthesis of nano-capsules via aqueous emulsion RCMP-PISA and encapsulation",

abstract = "Biocompatible nano-capsules (polymer vesicles) were prepared by combining NaI-catalyzed living radical polymerization with aqueous emulsion PISA (polymerization induced self-assembly). Poly(ethylene glycol) methyl ether methacrylate (PEGMA) and methyl methacrylate (MMA) were used as hydrophilic and hydrophobic monomers, respectively. Spheres and vesicles were generated depending on the degrees of polymerization of the hydrophilic and hydrophobic segments in the block copolymers. The spheres and vesicles were crosslinked using a divinyl monomer (ethylene glycol dimethacrylate (EGDMA)) as a co-monomer of MMA in situ during the polymerization. The encapsulation ability of the obtained vesicle was studied using a hydrophilic dye, i.e., rhodamine-B.",

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AU - Sarkar, Jit

AU - Jackson, Alexander W.

AU - Van Herk, Alexander M.

AU - Goto, Atsushi

PY - 2020/6/21

Y1 - 2020/6/21

N2 - Biocompatible nano-capsules (polymer vesicles) were prepared by combining NaI-catalyzed living radical polymerization with aqueous emulsion PISA (polymerization induced self-assembly). Poly(ethylene glycol) methyl ether methacrylate (PEGMA) and methyl methacrylate (MMA) were used as hydrophilic and hydrophobic monomers, respectively. Spheres and vesicles were generated depending on the degrees of polymerization of the hydrophilic and hydrophobic segments in the block copolymers. The spheres and vesicles were crosslinked using a divinyl monomer (ethylene glycol dimethacrylate (EGDMA)) as a co-monomer of MMA in situ during the polymerization. The encapsulation ability of the obtained vesicle was studied using a hydrophilic dye, i.e., rhodamine-B.

AB - Biocompatible nano-capsules (polymer vesicles) were prepared by combining NaI-catalyzed living radical polymerization with aqueous emulsion PISA (polymerization induced self-assembly). Poly(ethylene glycol) methyl ether methacrylate (PEGMA) and methyl methacrylate (MMA) were used as hydrophilic and hydrophobic monomers, respectively. Spheres and vesicles were generated depending on the degrees of polymerization of the hydrophilic and hydrophobic segments in the block copolymers. The spheres and vesicles were crosslinked using a divinyl monomer (ethylene glycol dimethacrylate (EGDMA)) as a co-monomer of MMA in situ during the polymerization. The encapsulation ability of the obtained vesicle was studied using a hydrophilic dye, i.e., rhodamine-B.

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Synthesis of nano-capsules via aqueous emulsion RCMP-PISA and encapsulation

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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