Synthesis of primary amines and N-methylamines by the electrophilic amination of Grignard reagents with 2-imidazolidinone O-sulfonyloxime

Mitsuru Kitamura, Shunsuke Chiba, Koichi Narasaka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

2-Imidazolidinone O-sulfonyloxime reacts with various aryl and alkyl Grignard reagents as an electrophilic amination reagent, giving N-alkylated imines. The resulting imines are transformed to primary amines and N-methyl secondary amines by hydrolysis with CsOH and LiAlH4 reduction, respectively.

Original languageEnglish
Pages (from-to)1063-1070
Number of pages8
JournalBulletin of the Chemical Society of Japan
Volume76
Issue number5
DOIs
Publication statusPublished - May 2003
Externally publishedYes

ASJC Scopus Subject Areas

  • General Chemistry

Fingerprint

Dive into the research topics of 'Synthesis of primary amines and N-methylamines by the electrophilic amination of Grignard reagents with 2-imidazolidinone O-sulfonyloxime'. Together they form a unique fingerprint.

Cite this