Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes.

Roderick W. Bates*, Rosalina Fernández-Moro, Steven V. Ley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Synthesis of the esterase inhibitor valilactone (1) is reported employing the oxidation of π-allyltricarbonyliron lactone complexes with ceric ammonium nitrate to afford the inherent β-lactone ring.

Original languageEnglish
Pages (from-to)2651-2654
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number23
DOIs
Publication statusPublished - Jun 3 1991
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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