Synthesis of Viriditins A and B by Selective Coupling of Trans-1,2-Dichloroethylene

Feddro Gilbert Wijaya; Sopan Pralhad Khandare; Dániel Csókás; Raghunath O. Ramabhadran; Roderick W. Bates

doi:10.1021/acs.joc.4c02975

Synthesis of Viriditins A and B by Selective Coupling of Trans-1,2-Dichloroethylene

Feddro Gilbert Wijaya, Sopan Pralhad Khandare, Dániel Csókás, Raghunath O. Ramabhadran, Roderick W. Bates^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A synthesis of (−)-viriditin A and (−)-viriditin B has been completed sequentially using a Suzuki coupling and a Heck reaction of trans-1,2-dichloroethylene. The selectivity for monocoupling of trans-1,2-dichloroethylene is attributed to a lower-energy transition state for the oxidative addition step.

Original language	English
Journal	Journal of Organic Chemistry
DOIs	https://doi.org/10.1021/acs.joc.4c02975
Publication status	Accepted/In press - 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2025 American Chemical Society.

ASJC Scopus Subject Areas

Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.joc.4c02975

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title = "Synthesis of Viriditins A and B by Selective Coupling of Trans-1,2-Dichloroethylene",

abstract = "A synthesis of (−)-viriditin A and (−)-viriditin B has been completed sequentially using a Suzuki coupling and a Heck reaction of trans-1,2-dichloroethylene. The selectivity for monocoupling of trans-1,2-dichloroethylene is attributed to a lower-energy transition state for the oxidative addition step.",

author = "Wijaya, {Feddro Gilbert} and Khandare, {Sopan Pralhad} and D{\'a}niel Cs{\'o}k{\'a}s and Ramabhadran, {Raghunath O.} and Bates, {Roderick W.}",

note = "Publisher Copyright: {\textcopyright} 2025 American Chemical Society.",

year = "2025",

doi = "10.1021/acs.joc.4c02975",

language = "English",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - Synthesis of Viriditins A and B by Selective Coupling of Trans-1,2-Dichloroethylene

AU - Wijaya, Feddro Gilbert

AU - Khandare, Sopan Pralhad

AU - Csókás, Dániel

AU - Ramabhadran, Raghunath O.

AU - Bates, Roderick W.

PY - 2025

Y1 - 2025

N2 - A synthesis of (−)-viriditin A and (−)-viriditin B has been completed sequentially using a Suzuki coupling and a Heck reaction of trans-1,2-dichloroethylene. The selectivity for monocoupling of trans-1,2-dichloroethylene is attributed to a lower-energy transition state for the oxidative addition step.

AB - A synthesis of (−)-viriditin A and (−)-viriditin B has been completed sequentially using a Suzuki coupling and a Heck reaction of trans-1,2-dichloroethylene. The selectivity for monocoupling of trans-1,2-dichloroethylene is attributed to a lower-energy transition state for the oxidative addition step.

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UR - http://www.scopus.com/inward/citedby.url?scp=105002743985&partnerID=8YFLogxK

U2 - 10.1021/acs.joc.4c02975

DO - 10.1021/acs.joc.4c02975

M3 - Article

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SN - 0022-3263

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

ER -

Synthesis of Viriditins A and B by Selective Coupling of Trans-1,2-Dichloroethylene

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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