Synthetic studies toward the total synthesis of tedanolide: assembly of the C1-C23 carbon backbone

Chek Ming Wong; Teck Peng Loh

doi:10.1016/j.tetlet.2006.04.044

Synthetic studies toward the total synthesis of tedanolide: assembly of the C1-C23 carbon backbone

Chek Ming Wong, Teck Peng Loh^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A stereoselective assembly of the C1-C23 fragment representing the carbon backbone of tedanolide was accomplished utilizing a chiral boron reagent to effect the aldol coupling of the C1-C12 diketoester fragment with the C13-C23 aldehyde fragment.

Original language	English
Pages (from-to)	4485-4489
Number of pages	5
Journal	Tetrahedron Letters
Volume	47
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2006.04.044
Publication status	Published - Jun 26 2006
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Aldol
Boron reagent
Fragment assembly
Stereoselective
Tedanolide

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10.1016/j.tetlet.2006.04.044

Cite this

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title = "Synthetic studies toward the total synthesis of tedanolide: assembly of the C1-C23 carbon backbone",

abstract = "A stereoselective assembly of the C1-C23 fragment representing the carbon backbone of tedanolide was accomplished utilizing a chiral boron reagent to effect the aldol coupling of the C1-C12 diketoester fragment with the C13-C23 aldehyde fragment.",

keywords = "Aldol, Boron reagent, Fragment assembly, Stereoselective, Tedanolide",

author = "Wong, \{Chek Ming\} and Loh, \{Teck Peng\}",

year = "2006",

month = jun,

day = "26",

doi = "10.1016/j.tetlet.2006.04.044",

language = "English",

volume = "47",

pages = "4485--4489",

journal = "Tetrahedron Letters",

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T1 - Synthetic studies toward the total synthesis of tedanolide

T2 - assembly of the C1-C23 carbon backbone

AU - Wong, Chek Ming

AU - Loh, Teck Peng

PY - 2006/6/26

Y1 - 2006/6/26

N2 - A stereoselective assembly of the C1-C23 fragment representing the carbon backbone of tedanolide was accomplished utilizing a chiral boron reagent to effect the aldol coupling of the C1-C12 diketoester fragment with the C13-C23 aldehyde fragment.

AB - A stereoselective assembly of the C1-C23 fragment representing the carbon backbone of tedanolide was accomplished utilizing a chiral boron reagent to effect the aldol coupling of the C1-C12 diketoester fragment with the C13-C23 aldehyde fragment.

KW - Aldol

KW - Boron reagent

KW - Fragment assembly

KW - Stereoselective

KW - Tedanolide

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U2 - 10.1016/j.tetlet.2006.04.044

DO - 10.1016/j.tetlet.2006.04.044

M3 - Article

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SN - 0040-4039

VL - 47

SP - 4485

EP - 4489

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

Synthetic studies toward the total synthesis of tedanolide: assembly of the C1-C23 carbon backbone

Abstract

ASJC Scopus Subject Areas

Keywords

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