Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

Shu Sin Chng; Truong Giang Hoang; Wei Woon Wayne Lee; Mun Pun Tham; Hui Yvonne Ling; Teck Peng Loh

doi:10.1016/j.tetlet.2004.10.146

Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

Shu Sin Chng, Truong Giang Hoang, Wei Woon Wayne Lee, Mun Pun Tham, Hui Yvonne Ling, Teck Peng Loh

National University of Singapore

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M ^pro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.

Original language	English
Pages (from-to)	9501-9504
Number of pages	4
Journal	Tetrahedron Letters
Volume	45
Issue number	52
DOIs	https://doi.org/10.1016/j.tetlet.2004.10.146
Publication status	Published - Dec 20 2004
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

AG7088
Anti-SARS agents
Diastereoselective
Indium-mediated allylation

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10.1016/j.tetlet.2004.10.146

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T2 - Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

AU - Chng, Shu Sin

AU - Hoang, Truong Giang

AU - Wayne Lee, Wei Woon

AU - Tham, Mun Pun

AU - Ling, Hui Yvonne

AU - Loh, Teck Peng

PY - 2004/12/20

Y1 - 2004/12/20

N2 - AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M pro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.

AB - AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M pro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.

KW - AG7088

KW - Anti-SARS agents

KW - Diastereoselective

KW - Indium-mediated allylation

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ER -

Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

Abstract

ASJC Scopus Subject Areas

Keywords

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