Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives

Ankur Harish Shah; Ivan Djordjevic; Terry W.J. Steele

doi:10.1016/j.jmbbm.2019.103405

Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives

Ankur Harish Shah, Ivan Djordjevic, Terry W.J. Steele^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Lack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. Non-aqueous liquid PEG 400 reinforced with high molecular weight PEGs (2 kDa, 6 kDA and 10 kDa) dissolved PDz to form tertiary blends for optimization of viscosity and shear storage modulus. Dynamic photorheometry correlated PEG molar mass and tertiary ratios to adhesion strength, swelling-in-water profile and potential weight loss in aqueous medium. Tertiary blended adhesives demonstrate an improvement in elongation and adhesion strength compared to the binary blends used as control.

Original language	English
Article number	103405
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	101
DOIs	https://doi.org/10.1016/j.jmbbm.2019.103405
Publication status	Published - Jan 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

ASJC Scopus Subject Areas

Biomaterials
Biomedical Engineering
Mechanics of Materials

Keywords

Bioadhesive
Carbene
Dendrimer
Polyethylene glycol
Polymer blend
UVA crosslink

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10.1016/j.jmbbm.2019.103405

Cite this

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title = "Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives",

abstract = "Lack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. Non-aqueous liquid PEG 400 reinforced with high molecular weight PEGs (2 kDa, 6 kDA and 10 kDa) dissolved PDz to form tertiary blends for optimization of viscosity and shear storage modulus. Dynamic photorheometry correlated PEG molar mass and tertiary ratios to adhesion strength, swelling-in-water profile and potential weight loss in aqueous medium. Tertiary blended adhesives demonstrate an improvement in elongation and adhesion strength compared to the binary blends used as control.",

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AU - Shah, Ankur Harish

AU - Djordjevic, Ivan

AU - Steele, Terry W.J.

PY - 2020/1

Y1 - 2020/1

N2 - Lack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. Non-aqueous liquid PEG 400 reinforced with high molecular weight PEGs (2 kDa, 6 kDA and 10 kDa) dissolved PDz to form tertiary blends for optimization of viscosity and shear storage modulus. Dynamic photorheometry correlated PEG molar mass and tertiary ratios to adhesion strength, swelling-in-water profile and potential weight loss in aqueous medium. Tertiary blended adhesives demonstrate an improvement in elongation and adhesion strength compared to the binary blends used as control.

AB - Lack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. Non-aqueous liquid PEG 400 reinforced with high molecular weight PEGs (2 kDa, 6 kDA and 10 kDa) dissolved PDz to form tertiary blends for optimization of viscosity and shear storage modulus. Dynamic photorheometry correlated PEG molar mass and tertiary ratios to adhesion strength, swelling-in-water profile and potential weight loss in aqueous medium. Tertiary blended adhesives demonstrate an improvement in elongation and adhesion strength compared to the binary blends used as control.

KW - Bioadhesive

KW - Carbene

KW - Dendrimer

KW - Polyethylene glycol

KW - Polymer blend

KW - UVA crosslink

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Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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