The dithiolate-bridged diiron hexacarbonyl complex Na2[(μ- SCH2CH2COO)Fe(CO)3]2 as a water-soluble photoCORM

Hwa Tiong Poh; Bai Ting Sim; Tsz Sian Chwee; Weng Kee Leong; Wai Yip Fan

doi:10.1021/om401013a

The dithiolate-bridged diiron hexacarbonyl complex Na₂[(μ- SCH₂CH₂COO)Fe(CO)₃]₂ as a water-soluble photoCORM

Hwa Tiong Poh, Bai Ting Sim, Tsz Sian Chwee, Weng Kee Leong, Wai Yip Fan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The water-soluble dimercaptopropanoate-bridged diiron hexacarbonyl complex Na₂[(μ-SCH₂CH₂COO)Fe(CO)₃] ₂ has been prepared, and the X-ray crystal structure and infrared, UV-visible, and ESI spectra of the complex have been obtained. The complex is shown to behave as a photoCORM, whereby all six CO ligands are released within 30 min of visible-light irradiation. Gas-phase FTIR spectroscopy has been used to quantify the release of CO into the headspace above the aqueous solution. The resulting product, tentatively assigned to an iron thiolate salt, is also water-soluble. Cell viability studies show that Na₂[(μ-SCH ₂CH₂COO)Fe(CO)₃]₂ is not cytotoxic toward normal epithelial cells.

Original language	English
Pages (from-to)	959-963
Number of pages	5
Journal	Organometallics
Volume	33
Issue number	4
DOIs	https://doi.org/10.1021/om401013a
Publication status	Published - Feb 24 2014
Externally published	Yes

ASJC Scopus Subject Areas

Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "The dithiolate-bridged diiron hexacarbonyl complex Na2[(μ- SCH2CH2COO)Fe(CO)3]2 as a water-soluble photoCORM",

abstract = "The water-soluble dimercaptopropanoate-bridged diiron hexacarbonyl complex Na2[(μ-SCH2CH2COO)Fe(CO)3] 2 has been prepared, and the X-ray crystal structure and infrared, UV-visible, and ESI spectra of the complex have been obtained. The complex is shown to behave as a photoCORM, whereby all six CO ligands are released within 30 min of visible-light irradiation. Gas-phase FTIR spectroscopy has been used to quantify the release of CO into the headspace above the aqueous solution. The resulting product, tentatively assigned to an iron thiolate salt, is also water-soluble. Cell viability studies show that Na2[(μ-SCH 2CH2COO)Fe(CO)3]2 is not cytotoxic toward normal epithelial cells.",

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AU - Poh, Hwa Tiong

AU - Sim, Bai Ting

AU - Chwee, Tsz Sian

AU - Leong, Weng Kee

AU - Fan, Wai Yip

PY - 2014/2/24

Y1 - 2014/2/24

N2 - The water-soluble dimercaptopropanoate-bridged diiron hexacarbonyl complex Na2[(μ-SCH2CH2COO)Fe(CO)3] 2 has been prepared, and the X-ray crystal structure and infrared, UV-visible, and ESI spectra of the complex have been obtained. The complex is shown to behave as a photoCORM, whereby all six CO ligands are released within 30 min of visible-light irradiation. Gas-phase FTIR spectroscopy has been used to quantify the release of CO into the headspace above the aqueous solution. The resulting product, tentatively assigned to an iron thiolate salt, is also water-soluble. Cell viability studies show that Na2[(μ-SCH 2CH2COO)Fe(CO)3]2 is not cytotoxic toward normal epithelial cells.

AB - The water-soluble dimercaptopropanoate-bridged diiron hexacarbonyl complex Na2[(μ-SCH2CH2COO)Fe(CO)3] 2 has been prepared, and the X-ray crystal structure and infrared, UV-visible, and ESI spectra of the complex have been obtained. The complex is shown to behave as a photoCORM, whereby all six CO ligands are released within 30 min of visible-light irradiation. Gas-phase FTIR spectroscopy has been used to quantify the release of CO into the headspace above the aqueous solution. The resulting product, tentatively assigned to an iron thiolate salt, is also water-soluble. Cell viability studies show that Na2[(μ-SCH 2CH2COO)Fe(CO)3]2 is not cytotoxic toward normal epithelial cells.

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The dithiolate-bridged diiron hexacarbonyl complex Na₂[(μ- SCH₂CH₂COO)Fe(CO)₃]₂ as a water-soluble photoCORM

Abstract

ASJC Scopus Subject Areas

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