The DNA-polymerase-X family: Controllers of DNA quality?

Kristijan Ramadan; Igor Shevelev; Ulrich Hübscher

doi:10.1038/nrm1530

The DNA-polymerase-X family: Controllers of DNA quality?

Kristijan Ramadan, Igor Shevelev, Ulrich Hübscher^*

^*Corresponding author for this work

University of Zurich

Research output: Contribution to journal › Review article › peer-review

71 Citations (Scopus)

Abstract

Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

Original language	English
Pages (from-to)	1038-1043
Number of pages	6
Journal	Nature Reviews Molecular Cell Biology
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nrm1530
Publication status	Published - Dec 2004
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Biology
Cell Biology

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10.1038/nrm1530

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title = "The DNA-polymerase-X family: Controllers of DNA quality?",

abstract = "Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.",

author = "Kristijan Ramadan and Igor Shevelev and Ulrich H{\"u}bscher",

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N2 - Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

AB - Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

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The DNA-polymerase-X family: Controllers of DNA quality?

Abstract

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