The effect of anticholinergic agents on gastro-oesophageal reflux and related disorders

Eva M. van Soest; Jeanne P. Dieleman; Ernst J. Kuipers

doi:10.1517/14740338.7.2.173

The effect of anticholinergic agents on gastro-oesophageal reflux and related disorders

Eva M. van Soest^*, Jeanne P. Dieleman, Ernst J. Kuipers

^*Corresponding author for this work

Erasmus University Rotterdam

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

The most important risk factor of oesophageal adenocarcinoma is gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease is in itself a common disorder, giving bothersome symptoms. In daily clinical practice, anticholinergic drugs are believed to increase the risk of gastro-oesophageal reflux through effects on the lower oesophageal sphincter. In this review we discuss the available literature on the potential association between the use of drugs with anticholinergic properties and the risk of gastro-oesophageal reflux-related disorders.

Original language	English
Pages (from-to)	173-180
Number of pages	8
Journal	Expert Opinion on Drug Safety
Volume	7
Issue number	2
DOIs	https://doi.org/10.1517/14740338.7.2.173
Publication status	Published - Mar 2008
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology (medical)

Keywords

Anticholinergic agents
Atropine
Gastro-oesophageal reflux disease
Oesophageal adenocarcinoma
Tricyclic antidepressants

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10.1517/14740338.7.2.173

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abstract = "The most important risk factor of oesophageal adenocarcinoma is gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease is in itself a common disorder, giving bothersome symptoms. In daily clinical practice, anticholinergic drugs are believed to increase the risk of gastro-oesophageal reflux through effects on the lower oesophageal sphincter. In this review we discuss the available literature on the potential association between the use of drugs with anticholinergic properties and the risk of gastro-oesophageal reflux-related disorders.",

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AB - The most important risk factor of oesophageal adenocarcinoma is gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease is in itself a common disorder, giving bothersome symptoms. In daily clinical practice, anticholinergic drugs are believed to increase the risk of gastro-oesophageal reflux through effects on the lower oesophageal sphincter. In this review we discuss the available literature on the potential association between the use of drugs with anticholinergic properties and the risk of gastro-oesophageal reflux-related disorders.

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KW - Oesophageal adenocarcinoma

KW - Tricyclic antidepressants

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The effect of anticholinergic agents on gastro-oesophageal reflux and related disorders

Abstract

ASJC Scopus Subject Areas

Keywords

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