TY - JOUR
T1 - The effect of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region in healthy young men
AU - Schmetterer, Leopold
AU - Wolzt, Michael
AU - Lexer, Franz
AU - Alschinger, Christa
AU - Gouya, Ghazaleh
AU - Zanaschka, Gabriele
AU - Fassolt, Anita
AU - Eichler, Hans Georg
AU - Fercher, Adolf Friedrich
PY - 1995/12
Y1 - 1995/12
N2 - The purpose of this study was to investigate the influence of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region and determine a potential autoregulative capacity of the choroid under these conditions. In a randomized cross-over study 100% O2 and a mixture of 5% CO2 with air was inhaled for 10 min by ten healthy male volunteers on different study days. Fundus pulsations were measured with a recently described laser interferometer. These results were compared to changes in systemic haemodynamics and Doppler-sonographic measurements of the radial artery. The fundus pulsation amplitude significantly decreased during hyperoxia and significantly increased during hypercapnia. These effects on fundus pulsations were stronger in the optic disc region than in the macular region. The systemic parameters showed only minor changes. Hence the amplitudes of fundus pulsations measured during hyperoxia and hypercapnia are assumed to be a consequence of metabolic autoregulative mechanisms. This autoregulative capacity is greater in the optic disc region than in the macular region, implying that the fundus pulsation amplitude in the papilla is influenced by both the choroidal and the retinal circulation.
AB - The purpose of this study was to investigate the influence of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region and determine a potential autoregulative capacity of the choroid under these conditions. In a randomized cross-over study 100% O2 and a mixture of 5% CO2 with air was inhaled for 10 min by ten healthy male volunteers on different study days. Fundus pulsations were measured with a recently described laser interferometer. These results were compared to changes in systemic haemodynamics and Doppler-sonographic measurements of the radial artery. The fundus pulsation amplitude significantly decreased during hyperoxia and significantly increased during hypercapnia. These effects on fundus pulsations were stronger in the optic disc region than in the macular region. The systemic parameters showed only minor changes. Hence the amplitudes of fundus pulsations measured during hyperoxia and hypercapnia are assumed to be a consequence of metabolic autoregulative mechanisms. This autoregulative capacity is greater in the optic disc region than in the macular region, implying that the fundus pulsation amplitude in the papilla is influenced by both the choroidal and the retinal circulation.
KW - autoregulation
KW - choroidal circulation
KW - fundus pulsations
KW - hypercapnia
KW - hyperoxia
KW - laser interferometry
KW - optic disc blood supply
KW - pulsatile ocular blood flow
UR - http://www.scopus.com/inward/record.url?scp=0029613845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029613845&partnerID=8YFLogxK
U2 - 10.1016/S0014-4835(05)80019-3
DO - 10.1016/S0014-4835(05)80019-3
M3 - Article
C2 - 8846840
AN - SCOPUS:0029613845
SN - 0014-4835
VL - 61
SP - 685
EP - 690
JO - Experimental Eye Research
JF - Experimental Eye Research
IS - 6
ER -