The first Bischler-Napieralski cyclization in a room temperature ionic liquid

Zaher M.A. Judeh; Chi Bun Ching; Jie Bu; Adam McCluskey

doi:10.1016/S0040-4039(02)00998-X

The first Bischler-Napieralski cyclization in a room temperature ionic liquid

Zaher M.A. Judeh^*, Chi Bun Ching, Jie Bu, Adam McCluskey

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF₆), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler-Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated.

Original language	English
Pages (from-to)	5089-5091
Number of pages	3
Journal	Tetrahedron Letters
Volume	43
Issue number	29
DOIs	https://doi.org/10.1016/S0040-4039(02)00998-X
Publication status	Published - Jul 15 2002
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Bischler-Napieralski cyclization
Ionic liquids
Isoquinolines

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10.1016/S0040-4039(02)00998-X

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abstract = "We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF6), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler-Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated.",

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AU - Judeh, Zaher M.A.

AU - Ching, Chi Bun

AU - Bu, Jie

AU - McCluskey, Adam

PY - 2002/7/15

Y1 - 2002/7/15

N2 - We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF6), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler-Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated.

AB - We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF6), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler-Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated.

KW - Bischler-Napieralski cyclization

KW - Ionic liquids

KW - Isoquinolines

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 29

ER -

The first Bischler-Napieralski cyclization in a room temperature ionic liquid

Abstract

ASJC Scopus Subject Areas

Keywords

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