TY - JOUR
T1 - The GenomeAsia 100K Project enables genetic discoveries across Asia
AU - GenomeAsia100K Consortium
AU - Wall, Jeffrey D.
AU - Stawiski, Eric W.
AU - Ratan, Aakrosh
AU - Kim, Hie Lim
AU - Kim, Changhoon
AU - Gupta, Ravi
AU - Suryamohan, Kushal
AU - Gusareva, Elena S.
AU - Purbojati, Rikky Wenang
AU - Bhangale, Tushar
AU - Stepanov, Vadim
AU - Kharkov, Vladimir
AU - Schröder, Markus S.
AU - Ramprasad, Vedam
AU - Tom, Jennifer
AU - Durinck, Steffen
AU - Bei, Qixin
AU - Li, Jiani
AU - Guillory, Joseph
AU - Phalke, Sameer
AU - Basu, Analabha
AU - Stinson, Jeremy
AU - Nair, Sandhya
AU - Malaichamy, Sivasankar
AU - Biswas, Nidhan K.
AU - Chambers, John C.
AU - Cheng, Keith C.
AU - George, Joyner T.
AU - Khor, Seik Soon
AU - Kim, Jong Il
AU - Cho, Belong
AU - Menon, Ramesh
AU - Sattibabu, Thiramsetti
AU - Bassi, Akshi
AU - Deshmukh, Manjari
AU - Verma, Anjali
AU - Gopalan, Vivek
AU - Shin, Jong Yeon
AU - Pratapneni, Mahesh
AU - Santhosh, Sam
AU - Tokunaga, Katsushi
AU - Md-Zain, Badrul M.
AU - Chan, Kok Gan
AU - Parani, Madasamy
AU - Natarajan, Purushothaman
AU - Hauser, Michael
AU - Allingham, R. Rand
AU - Santiago-Turla, Cecilia
AU - Ghosh, Arkasubhra
AU - Schuster, Stephan C.
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/5
Y1 - 2019/12/5
N2 - The underrepresentation of non-Europeans in human genetic studies so far has limited the diversity of individuals in genomic datasets and led to reduced medical relevance for a large proportion of the world’s population. Population-specific reference genome datasets as well as genome-wide association studies in diverse populations are needed to address this issue. Here we describe the pilot phase of the GenomeAsia 100K Project. This includes a whole-genome sequencing reference dataset from 1,739 individuals of 219 population groups and 64 countries across Asia. We catalogue genetic variation, population structure, disease associations and founder effects. We also explore the use of this dataset in imputation, to facilitate genetic studies in populations across Asia and worldwide.
AB - The underrepresentation of non-Europeans in human genetic studies so far has limited the diversity of individuals in genomic datasets and led to reduced medical relevance for a large proportion of the world’s population. Population-specific reference genome datasets as well as genome-wide association studies in diverse populations are needed to address this issue. Here we describe the pilot phase of the GenomeAsia 100K Project. This includes a whole-genome sequencing reference dataset from 1,739 individuals of 219 population groups and 64 countries across Asia. We catalogue genetic variation, population structure, disease associations and founder effects. We also explore the use of this dataset in imputation, to facilitate genetic studies in populations across Asia and worldwide.
UR - http://www.scopus.com/inward/record.url?scp=85076121527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076121527&partnerID=8YFLogxK
U2 - 10.1038/s41586-019-1793-z
DO - 10.1038/s41586-019-1793-z
M3 - Article
C2 - 31802016
AN - SCOPUS:85076121527
SN - 0028-0836
VL - 576
SP - 106
EP - 111
JO - Nature
JF - Nature
IS - 7785
ER -
