Abstract
Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering.
| Original language | English |
|---|---|
| Article number | 367 |
| Journal | Materials |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Mar 31 2017 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
ASJC Scopus Subject Areas
- General Materials Science
- Condensed Matter Physics
Keywords
- Compressive strengths
- Freeze-casting
- Graded structure
- Porosity
- Porous materials