The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology

Thomas E. Wood; Sophie A. Howard; Andreas Förster; Laura M. Nolan; Eleni Manoli; Nathan P. Bullen; Hamish C.L. Yau; Abderrahman Hachani; Richard D. Hayward; John C. Whitney; Waldemar Vollmer; Paul S. Freemont; Alain Filloux

doi:10.1016/j.celrep.2019.08.094

The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology

Thomas E. Wood, Sophie A. Howard, Andreas Förster, Laura M. Nolan, Eleni Manoli, Nathan P. Bullen, Hamish C.L. Yau, Abderrahman Hachani, Richard D. Hayward, John C. Whitney, Waldemar Vollmer, Paul S. Freemont, Alain Filloux^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

The bacterial type VI secretion system (T6SS) delivers effector proteins into prokaryotic and eukaryotic cells to enhance the survival of the donor cell. Wood et al. describe an antibacterial T6SS toxin family eliciting a profound cell division defect and lysis. The structure of this periplasmic-acting toxin reveals a metallopeptidase fold.

Original language	English
Pages (from-to)	187-201.e7
Journal	Cell Reports
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2019.08.094
Publication status	Published - Oct 1 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Authors

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

effector
metallopeptidase
Pseudomonas aeruginosa
type VI secretion system
VgrG

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10.1016/j.celrep.2019.08.094

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Wood, T. E., Howard, S. A., Förster, A., Nolan, L. M., Manoli, E., Bullen, N. P., Yau, H. C. L., Hachani, A., Hayward, R. D., Whitney, J. C., Vollmer, W., Freemont, P. S., & Filloux, A. (2019). The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology. Cell Reports, 29(1), 187-201.e7. https://doi.org/10.1016/j.celrep.2019.08.094

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abstract = "The bacterial type VI secretion system (T6SS) delivers effector proteins into prokaryotic and eukaryotic cells to enhance the survival of the donor cell. Wood et al. describe an antibacterial T6SS toxin family eliciting a profound cell division defect and lysis. The structure of this periplasmic-acting toxin reveals a metallopeptidase fold.",

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The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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