The role of Helicobacter pylori virulence factors in interleukin production by monocytic cells

Ramon De Jonge; Johannes G. Kusters; Marieke S. Timmer; Verena Gimmel; Ben J. Appelmelk; Stefan Bereswill; Arnoud H.M. Van Vliet; Stefan G.M. Meuwissen; Manfred Kist; Christina M.J.E. Vandenbroucke-Grauls; Ernst J. Kuipers

doi:10.1016/S0378-1097(01)00074-X

The role of Helicobacter pylori virulence factors in interleukin production by monocytic cells

Ramon De Jonge^*, Johannes G. Kusters, Marieke S. Timmer, Verena Gimmel, Ben J. Appelmelk, Stefan Bereswill, Arnoud H.M. Van Vliet, Stefan G.M. Meuwissen, Manfred Kist, Christina M.J.E. Vandenbroucke-Grauls, Ernst J. Kuipers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Helicobacter pylori infection results in chronic gastritis, which is initiated by the release of cytokines like interleukin (IL)-12 and IL-8 from mononuclear cells, and IL-8 from gastric epithelial cells. The severity of gastritis is influenced both by host factors and by bacterial factors such as the Cag proteins and the vacuolating cytotoxin VacA. Amounts of IL-12 and IL-8 produced by monocytic THP-1 cells differed considerably between the eight H. pylori isolates tested, but in contrast to H. pylori-induced IL-8 production by gastric epithelial cells, did not correlate to the Cag and VacA types of the strains. Apparently, in addition to Cag and VacA, other bacterial factors determine the extent in which H. pylori induced IL production in monocytes.

Original language	English
Pages (from-to)	235-238
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	196
Issue number	2
DOIs	https://doi.org/10.1016/S0378-1097(01)00074-X
Publication status	Published - Mar 15 2001
Externally published	Yes

ASJC Scopus Subject Areas

Microbiology
Molecular Biology
Genetics

Keywords

Cag pathogenicity island
Helicobacter pylori pathogenesis
Interleukin-12 production
T-helper 1 response
Vacuolating cytotoxin VacA

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10.1016/S0378-1097(01)00074-X

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De Jonge, R., Kusters, J. G., Timmer, M. S., Gimmel, V., Appelmelk, B. J., Bereswill, S., Van Vliet, A. H. M., Meuwissen, S. G. M., Kist, M., Vandenbroucke-Grauls, C. M. J. E., & Kuipers, E. J. (2001). The role of Helicobacter pylori virulence factors in interleukin production by monocytic cells. FEMS Microbiology Letters, 196(2), 235-238. https://doi.org/10.1016/S0378-1097(01)00074-X

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abstract = "Helicobacter pylori infection results in chronic gastritis, which is initiated by the release of cytokines like interleukin (IL)-12 and IL-8 from mononuclear cells, and IL-8 from gastric epithelial cells. The severity of gastritis is influenced both by host factors and by bacterial factors such as the Cag proteins and the vacuolating cytotoxin VacA. Amounts of IL-12 and IL-8 produced by monocytic THP-1 cells differed considerably between the eight H. pylori isolates tested, but in contrast to H. pylori-induced IL-8 production by gastric epithelial cells, did not correlate to the Cag and VacA types of the strains. Apparently, in addition to Cag and VacA, other bacterial factors determine the extent in which H. pylori induced IL production in monocytes.",

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doi = "10.1016/S0378-1097(01)00074-X",

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AU - Timmer, Marieke S.

AU - Gimmel, Verena

AU - Appelmelk, Ben J.

AU - Bereswill, Stefan

AU - Van Vliet, Arnoud H.M.

AU - Meuwissen, Stefan G.M.

AU - Kist, Manfred

AU - Vandenbroucke-Grauls, Christina M.J.E.

AU - Kuipers, Ernst J.

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AB - Helicobacter pylori infection results in chronic gastritis, which is initiated by the release of cytokines like interleukin (IL)-12 and IL-8 from mononuclear cells, and IL-8 from gastric epithelial cells. The severity of gastritis is influenced both by host factors and by bacterial factors such as the Cag proteins and the vacuolating cytotoxin VacA. Amounts of IL-12 and IL-8 produced by monocytic THP-1 cells differed considerably between the eight H. pylori isolates tested, but in contrast to H. pylori-induced IL-8 production by gastric epithelial cells, did not correlate to the Cag and VacA types of the strains. Apparently, in addition to Cag and VacA, other bacterial factors determine the extent in which H. pylori induced IL production in monocytes.

KW - Cag pathogenicity island

KW - Helicobacter pylori pathogenesis

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KW - T-helper 1 response

KW - Vacuolating cytotoxin VacA

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The role of Helicobacter pylori virulence factors in interleukin production by monocytic cells

Abstract

ASJC Scopus Subject Areas

Keywords

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