The ruthenium-catalyzed C-H functionalization of enamides with isocyanates: Easy entry to pyrimidin-4-ones

Pengfei Shi; Song Li; Lu Min Hu; Cong Wang; Teck Peng Loh; Xu Hong Hu

doi:10.1039/c9cc03612a

The ruthenium-catalyzed C-H functionalization of enamides with isocyanates: Easy entry to pyrimidin-4-ones

Pengfei Shi, Song Li, Lu Min Hu, Cong Wang, Teck Peng Loh, Xu Hong Hu

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Ruthenium-catalyzed heteroannulation between enamides and isocyanates has been realized as a complementary approach to conventional strategies for the synthesis of pyrimidin-4-ones. High step-A nd atom-economy was achieved for the rapid construction of such privileged scaffolds, which are found in a multitude of pharmaceutical compounds. The generality and practicability of this transformation were reflected by the broad scope of substrates with diverse functional groups, large-scale synthesis, and late-stage diversification.

Original language	English
Pages (from-to)	11115-11118
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	74
DOIs	https://doi.org/10.1039/c9cc03612a
Publication status	Published - 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
This journal is © The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc03612a

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abstract = "Ruthenium-catalyzed heteroannulation between enamides and isocyanates has been realized as a complementary approach to conventional strategies for the synthesis of pyrimidin-4-ones. High step-A nd atom-economy was achieved for the rapid construction of such privileged scaffolds, which are found in a multitude of pharmaceutical compounds. The generality and practicability of this transformation were reflected by the broad scope of substrates with diverse functional groups, large-scale synthesis, and late-stage diversification.",

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AU - Hu, Lu Min

AU - Wang, Cong

AU - Loh, Teck Peng

AU - Hu, Xu Hong

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

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AB - Ruthenium-catalyzed heteroannulation between enamides and isocyanates has been realized as a complementary approach to conventional strategies for the synthesis of pyrimidin-4-ones. High step-A nd atom-economy was achieved for the rapid construction of such privileged scaffolds, which are found in a multitude of pharmaceutical compounds. The generality and practicability of this transformation were reflected by the broad scope of substrates with diverse functional groups, large-scale synthesis, and late-stage diversification.

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The ruthenium-catalyzed C-H functionalization of enamides with isocyanates: Easy entry to pyrimidin-4-ones

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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