TY - JOUR
T1 - The Singapore National Precision Medicine Strategy
AU - SG10K_Health Consortium
AU - Wong, Eleanor
AU - Bertin, Nicolas
AU - Hebrard, Maxime
AU - Tirado-Magallanes, Roberto
AU - Bellis, Claire
AU - Lim, Weng Khong
AU - Chua, Chee Yong
AU - Tong, Philomena Mei Lin
AU - Chua, Raymond
AU - Mak, Kenneth
AU - Lim, Tit Meng
AU - Cheong, Wei Yang
AU - Thien, Kwee Eng
AU - Goh, Khean Teik
AU - Chai, Jin Fang
AU - Lee, Jimmy
AU - Sung, Joseph Jao Yiu
AU - Wong, Tien Yin
AU - Chin, Calvin Woon Loong
AU - Gluckman, Peter D.
AU - Goh, Liuh Ling
AU - Ban, Kenneth Hon Kim
AU - Tan, Tin Wee
AU - Van Dam, Rob M.
AU - Teo, Yik Ying
AU - Loh, Marie
AU - Eillot, Paul
AU - Lee, Eng Sing
AU - Ngeow, Joanne
AU - Riboli, Elio
AU - Dalan, Rinkoo
AU - Kassam, Irfahan
AU - Lakshmanan, Lakshmi Narayanan
AU - Lim, Tock Han
AU - Ng, Hong Kiat
AU - Mina, Theresia
AU - Tay, Darwin
AU - Sabanayagam, Charumathi
AU - Tham, Yih Chung
AU - Rim, Tyler
AU - Aung, Tin
AU - Chee, Miao Ling
AU - Li, Hengtong
AU - Chee, Miao Li
AU - Yeo, Khung Keong
AU - Cook, Stuart Alexander
AU - Pua, Chee Jian
AU - Yang, Chengxi
AU - Chong, Yap Seng
AU - Eriksson, Johan Gunnar
N1 - Publisher Copyright:
© 2023, Springer Nature America, Inc.
PY - 2023/2
Y1 - 2023/2
N2 - Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic–phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world’s population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption.
AB - Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic–phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world’s population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption.
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U2 - 10.1038/s41588-022-01274-x
DO - 10.1038/s41588-022-01274-x
M3 - Article
C2 - 36658435
AN - SCOPUS:85146854382
SN - 1061-4036
VL - 55
SP - 178
EP - 186
JO - Nature Genetics
JF - Nature Genetics
IS - 2
ER -