The Trinity of SPRTN Protease Regulation

Annamaria Ruggiano; Kristijan Ramadan

doi:10.1016/j.tibs.2020.10.007

The Trinity of SPRTN Protease Regulation

Annamaria Ruggiano, Kristijan Ramadan^*

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Short survey › peer-review

7 Citations (Scopus)

Abstract

The protease SPRTN emerged as the essential enzyme for DNA–protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA–protein crosslinks.

Original language	English
Pages (from-to)	2-4
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/j.tibs.2020.10.007
Publication status	Published - Jan 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology

Keywords

cancer
DNA–protein crosslinks
genomic instability
SPRTN protease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tibs.2020.10.007

Cite this

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abstract = "The protease SPRTN emerged as the essential enzyme for DNA–protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA–protein crosslinks.",

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author = "Annamaria Ruggiano and Kristijan Ramadan",

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year = "2021",

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AU - Ramadan, Kristijan

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AB - The protease SPRTN emerged as the essential enzyme for DNA–protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA–protein crosslinks.

KW - cancer

KW - DNA–protein crosslinks

KW - genomic instability

KW - SPRTN protease

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C2 - 33183910

AN - SCOPUS:85095839183

SN - 0968-0004

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The Trinity of SPRTN Protease Regulation

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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