TY - JOUR
T1 - Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing
AU - Prasad, Kenath Priyanka
AU - Than, Aung
AU - Li, Nan
AU - Alam Sk, Mahasin
AU - Duan, Hongwei
AU - Pu, Kanyi
AU - Zheng, Xinting
AU - Chen, Peng
N1 - Publisher Copyright:
© 2018 the Partner Organisations.
PY - 2017/1
Y1 - 2017/1
N2 - In this work, we present a new type of polymer dot synthesized from bithiophene (pTh-Pdot) via a simple and high yield procedure. Owing to their high brightness, excellent photo-stability, good biocompatibility, and molecular size, pTh-Pdots are promising for bioimaging applications. As a proof-of-concept demonstration, pTh-Pdots are herein employed to track the endocytic pathway in live cells. Furthermore, we show that these polymeric nanoparticles can serve as potent antibacterial agents by making use of their ability to disrupt bacterial membranes and high peroxidase mimicking activity.
AB - In this work, we present a new type of polymer dot synthesized from bithiophene (pTh-Pdot) via a simple and high yield procedure. Owing to their high brightness, excellent photo-stability, good biocompatibility, and molecular size, pTh-Pdots are promising for bioimaging applications. As a proof-of-concept demonstration, pTh-Pdots are herein employed to track the endocytic pathway in live cells. Furthermore, we show that these polymeric nanoparticles can serve as potent antibacterial agents by making use of their ability to disrupt bacterial membranes and high peroxidase mimicking activity.
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U2 - 10.1039/c6qm00065g
DO - 10.1039/c6qm00065g
M3 - Article
AN - SCOPUS:85014296124
SN - 2052-1537
VL - 1
SP - 152
EP - 157
JO - Materials Chemistry Frontiers
JF - Materials Chemistry Frontiers
IS - 1
ER -