Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (π-allyl)tricarbonyliron lactone complex

Roderick W. Bates; Eduardo Fernândez-Megia; Steven V. Ley; Karola Ruck-Braun; D. Matthew Tilbrook

doi:10.1039/a903641e

Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (π-allyl)tricarbonyliron lactone complex

Roderick W. Bates^*, Eduardo Fernândez-Megia, Steven V. Ley, Karola Ruck-Braun, D. Matthew Tilbrook

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The total synthesis of the β-lactone cholesterol synthase inhibitor 1233A (1) is described employing the oxidative decomplexation of a (π-allyl)tricarbonyliron lactone (2) as the key synthetic step.

Original language	English
Pages (from-to)	1917-1925
Number of pages	9
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	14
DOIs	https://doi.org/10.1039/a903641e
Publication status	Published - 1999
Externally published	Yes

ASJC Scopus Subject Areas

General Chemistry

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title = "Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (π-allyl)tricarbonyliron lactone complex",

abstract = "The total synthesis of the β-lactone cholesterol synthase inhibitor 1233A (1) is described employing the oxidative decomplexation of a (π-allyl)tricarbonyliron lactone (2) as the key synthetic step.",

author = "Bates, {Roderick W.} and Eduardo Fern{\^a}ndez-Megia and Ley, {Steven V.} and Karola Ruck-Braun and {Matthew Tilbrook}, D.",

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AU - Bates, Roderick W.

AU - Fernândez-Megia, Eduardo

AU - Ley, Steven V.

AU - Ruck-Braun, Karola

AU - Matthew Tilbrook, D.

PY - 1999

Y1 - 1999

N2 - The total synthesis of the β-lactone cholesterol synthase inhibitor 1233A (1) is described employing the oxidative decomplexation of a (π-allyl)tricarbonyliron lactone (2) as the key synthetic step.

AB - The total synthesis of the β-lactone cholesterol synthase inhibitor 1233A (1) is described employing the oxidative decomplexation of a (π-allyl)tricarbonyliron lactone (2) as the key synthetic step.

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DO - 10.1039/a903641e

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SP - 1917

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JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

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ER -

Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (π-allyl)tricarbonyliron lactone complex

Abstract

ASJC Scopus Subject Areas

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