Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os3(CO)10(NCCH3)2: Its reactivity with amino acids and oligopeptides

Joey Jia Ying Lee; Weng Kee Leong

doi:10.1016/j.jorganchem.2020.121459

Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂: Its reactivity with amino acids and oligopeptides

Joey Jia Ying Lee, Weng Kee Leong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The reactions of the triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ (1) with a number of protected amino acids, tri- and pentapeptides were examined. The results show that reaction with the side chains follow the order: -SH > -COOH > -CONH₂, and there is a slight preference for the longer side chain of glutamic acid over aspartic acid. The trends observed are retained under physiological conditions and in the peptides.

Original language	English
Article number	121459
Journal	Journal of Organometallic Chemistry
Volume	924
DOIs	https://doi.org/10.1016/j.jorganchem.2020.121459
Publication status	Published - Oct 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Materials Chemistry

Keywords

Amino acids
Carbonyl cluster
Cytotoxic
Oligopeptides
Osmium

Access to Document

10.1016/j.jorganchem.2020.121459

Cite this

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title = "Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os3(CO)10(NCCH3)2: Its reactivity with amino acids and oligopeptides",

abstract = "The reactions of the triosmium carbonyl cluster Os3(CO)10(NCCH3)2 (1) with a number of protected amino acids, tri- and pentapeptides were examined. The results show that reaction with the side chains follow the order: -SH > -COOH > -CONH2, and there is a slight preference for the longer side chain of glutamic acid over aspartic acid. The trends observed are retained under physiological conditions and in the peptides.",

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AU - Leong, Weng Kee

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AB - The reactions of the triosmium carbonyl cluster Os3(CO)10(NCCH3)2 (1) with a number of protected amino acids, tri- and pentapeptides were examined. The results show that reaction with the side chains follow the order: -SH > -COOH > -CONH2, and there is a slight preference for the longer side chain of glutamic acid over aspartic acid. The trends observed are retained under physiological conditions and in the peptides.

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KW - Cytotoxic

KW - Oligopeptides

KW - Osmium

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