Visible-light-induced regio- And stereoselective C(sp2)-H trifluoroethylation of enamides with 2,2,2-trifluoroethyl iodide

Kai Zhao; Ze Yu Zhang; Xian Lu Cui; Ying Xue Wang; Xian Dan Wu; Wei Ming Li; Jia Xu Wu; Li Li Zhao; Jing Yu Guo; Teck Peng Loh

doi:10.1021/acs.orglett.0c03418

Visible-light-induced regio- And stereoselective C(sp²)-H trifluoroethylation of enamides with 2,2,2-trifluoroethyl iodide

Kai Zhao, Ze Yu Zhang, Xian Lu Cui, Ying Xue Wang, Xian Dan Wu, Wei Ming Li, Jia Xu Wu, Li Li Zhao, Jing Yu Guo, Teck Peng Loh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.

Original language	English
Pages (from-to)	9029-9035
Number of pages	7
Journal	Organic Letters
Volume	22
Issue number	22
DOIs	https://doi.org/10.1021/acs.orglett.0c03418
Publication status	Published - Nov 20 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 American Chemical Society

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/acs.orglett.0c03418

Cite this

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title = "Visible-light-induced regio- And stereoselective C(sp2)-H trifluoroethylation of enamides with 2,2,2-trifluoroethyl iodide",

abstract = "A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.",

author = "Kai Zhao and Zhang, {Ze Yu} and Cui, {Xian Lu} and Wang, {Ying Xue} and Wu, {Xian Dan} and Li, {Wei Ming} and Wu, {Jia Xu} and Zhao, {Li Li} and Guo, {Jing Yu} and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society",

year = "2020",

month = nov,

day = "20",

doi = "10.1021/acs.orglett.0c03418",

language = "English",

volume = "22",

pages = "9029--9035",

journal = "Organic Letters",

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T1 - Visible-light-induced regio- And stereoselective C(sp2)-H trifluoroethylation of enamides with 2,2,2-trifluoroethyl iodide

AU - Zhao, Kai

AU - Zhang, Ze Yu

AU - Cui, Xian Lu

AU - Wang, Ying Xue

AU - Wu, Xian Dan

AU - Li, Wei Ming

AU - Wu, Jia Xu

AU - Zhao, Li Li

AU - Guo, Jing Yu

AU - Loh, Teck Peng

PY - 2020/11/20

Y1 - 2020/11/20

N2 - A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.

AB - A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.

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JO - Organic Letters

JF - Organic Letters

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