Water-Tolerant ortho-Acylation of Phenols

Jie Sheng Tian; Yu He; Zhi Yuan Gao; Xu Liu; Shuang Feng Dong; Peng Wu; Teck Peng Loh

doi:10.1021/acs.orglett.1c02583

Water-Tolerant ortho-Acylation of Phenols

Jie Sheng Tian^*, Yu He, Zhi Yuan Gao, Xu Liu, Shuang Feng Dong, Peng Wu, Teck Peng Loh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Original language	English
Pages (from-to)	6594-6598
Number of pages	5
Journal	Organic Letters
Volume	23
Issue number	16
DOIs	https://doi.org/10.1021/acs.orglett.1c02583
Publication status	Published - Aug 20 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.1c02583

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abstract = "A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.",

author = "Tian, \{Jie Sheng\} and Yu He and Gao, \{Zhi Yuan\} and Xu Liu and Dong, \{Shuang Feng\} and Peng Wu and Loh, \{Teck Peng\}",

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doi = "10.1021/acs.orglett.1c02583",

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AU - Tian, Jie Sheng

AU - He, Yu

AU - Gao, Zhi Yuan

AU - Liu, Xu

AU - Dong, Shuang Feng

AU - Wu, Peng

AU - Loh, Teck Peng

PY - 2021/8/20

Y1 - 2021/8/20

N2 - A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

AB - A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

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Water-Tolerant ortho-Acylation of Phenols

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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