Abstract
Hormonal changes associated with ageing have been implicated in cognitive decline and the pathogenesis of neurodegenerative disease such as Alzheimer’s disease (AD), the most common form of dementia. In particular, reductions in serum sex steroid (oestrogen and testosterone) and increases in the gonadotropin (luteinising hormone (LH)) are AD risk factors and have roles in neurodegeneration through promoting amyloid-β (Aβ) accumulation, oxidative stress, and inflammation. The underlying mechanisms by which these hormones contribute to neurodegeneration are not completely understood. This chapter will discuss current knowledge of these underlying mechanisms and will provide an update on therapeutic approaches targeting these hormones.
| Original language | English |
|---|---|
| Title of host publication | Neurodegeneration and Alzheimer’s Disease |
| Subtitle of host publication | The Role of Diabetes, Genetics, Hormones, and Lifestyle |
| Publisher | wiley |
| Pages | 335-369 |
| Number of pages | 35 |
| ISBN (Electronic) | 9781119356752 |
| ISBN (Print) | 9781119356783 |
| DOIs | |
| Publication status | Published - May 11 2019 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 John Wiley & Sons, Ltd.
ASJC Scopus Subject Areas
- General Engineering
- General Agricultural and Biological Sciences
Keywords
- Alzheimer’s disease
- Chronic inflammation
- Cognitive decline
- Combinational hormone therapy
- Gonadotropins
- Oxidative stress
- Reproductive senescence
- Sex steroids