Regulation of synaptic plasticity by hippocampus synthesized estradiol

Anna M. Barron; Yasushi Hojo; Hideo Mukai; Shimpei Higo; Yuuki Ooishi; Yusuke Hatanaka; Mari Ogiue-Ikeda; Gen Murakami; Tetsuya Kimoto; Suguru Kawato; Yasushi Hojo; Hideo Mukai; Tetsuya Kimoto; Suguru Kawato; Yasushi Hojo; Hideo Mukai; Gen Murakami; Tetsuya Kimoto; Suguru Kawato; Mari Ogiue-Ikeda; Suguru Kawato; Suguru Kawato

doi:10.1515/HMBCI.2011.118

Regulation of synaptic plasticity by hippocampus synthesized estradiol

Anna M. Barron, Yasushi Hojo, Hideo Mukai, Shimpei Higo, Yuuki Ooishi, Yusuke Hatanaka, Mari Ogiue-Ikeda, Gen Murakami, Tetsuya Kimoto, Suguru Kawato^*, Yasushi Hojo, Hideo Mukai, Tetsuya Kimoto, Suguru Kawato^*, Yasushi Hojo, Hideo Mukai, Gen Murakami, Tetsuya Kimoto, Suguru Kawato^*, Mari Ogiue-IkedaSuguru Kawato^*, Suguru Kawato^*

^*Corresponding author for this work

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Estradiol is synthesized from cholesterol in hippocampal neurons of adult rats by cytochrome P450 and hydroxyste-roid dehydrogenase enzymes. These enzymes are expressed in the glutamatergic neurons of the hippocampus. Surprisingly., the concentration of estradiol and androgen in the hippocampus is significantly higher than that in circulation. Locally synthesized estradiol rapidly and potently modulates synaptic plasticity within the hippocampus. E2 rapidly potentiates long-term depression and induces spinogenesis through synaptic estrogen receptors and kinases. The rapid effects of estradiol are followed by slow genomic effects mediated by both estrogen receptors located at the synapse and nucleus., modulating long-term potentiation and promoting the formation of new functional synaptic contacts. Age-related changes in hippocampally derived estradiol synthesis and distribution of estrogen receptors may alter synaptic plasticity., and could potentially contribute to age-related cognitive decline. Understanding factors which regulate hippocampal estradiol synthesis could lead to the identification of alternatives to conventional hormone therapy to protect against age-related cognitive decline.

Original language	English
Pages (from-to)	361-375
Number of pages	15
Journal	Hormone Molecular Biology and Clinical Investigation
Volume	7
Issue number	2
DOIs	https://doi.org/10.1515/HMBCI.2011.118
Publication status	Published - 2011
Externally published	Yes

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Endocrinology

Keywords

aging
estradiol
estrogen receptor
hippocampus
hormone therapy
long-term depression
long-term potentiation
neurosteroid
selective estrogen receptor modulator
spine
synaptic plasticity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/HMBCI.2011.118

Cite this

Barron, A. M., Hojo, Y., Mukai, H., Higo, S., Ooishi, Y., Hatanaka, Y., Ogiue-Ikeda, M., Murakami, G., Kimoto, T., Kawato, S., Hojo, Y., Mukai, H., Kimoto, T., Kawato, S., Hojo, Y., Mukai, H., Murakami, G., Kimoto, T., Kawato, S., ... Kawato, S. (2011). Regulation of synaptic plasticity by hippocampus synthesized estradiol. Hormone Molecular Biology and Clinical Investigation, 7(2), 361-375. https://doi.org/10.1515/HMBCI.2011.118

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title = "Regulation of synaptic plasticity by hippocampus synthesized estradiol",

abstract = "Estradiol is synthesized from cholesterol in hippocampal neurons of adult rats by cytochrome P450 and hydroxyste-roid dehydrogenase enzymes. These enzymes are expressed in the glutamatergic neurons of the hippocampus. Surprisingly., the concentration of estradiol and androgen in the hippocampus is significantly higher than that in circulation. Locally synthesized estradiol rapidly and potently modulates synaptic plasticity within the hippocampus. E2 rapidly potentiates long-term depression and induces spinogenesis through synaptic estrogen receptors and kinases. The rapid effects of estradiol are followed by slow genomic effects mediated by both estrogen receptors located at the synapse and nucleus., modulating long-term potentiation and promoting the formation of new functional synaptic contacts. Age-related changes in hippocampally derived estradiol synthesis and distribution of estrogen receptors may alter synaptic plasticity., and could potentially contribute to age-related cognitive decline. Understanding factors which regulate hippocampal estradiol synthesis could lead to the identification of alternatives to conventional hormone therapy to protect against age-related cognitive decline.",

keywords = "aging, estradiol, estrogen receptor, hippocampus, hormone therapy, long-term depression, long-term potentiation, neurosteroid, selective estrogen receptor modulator, spine, synaptic plasticity",

author = "Barron, {Anna M.} and Yasushi Hojo and Hideo Mukai and Shimpei Higo and Yuuki Ooishi and Yusuke Hatanaka and Mari Ogiue-Ikeda and Gen Murakami and Tetsuya Kimoto and Suguru Kawato and Yasushi Hojo and Hideo Mukai and Tetsuya Kimoto and Suguru Kawato and Yasushi Hojo and Hideo Mukai and Gen Murakami and Tetsuya Kimoto and Suguru Kawato and Mari Ogiue-Ikeda and Suguru Kawato and Suguru Kawato",

year = "2011",

doi = "10.1515/HMBCI.2011.118",

language = "English",

volume = "7",

pages = "361--375",

journal = "Hormone Molecular Biology and Clinical Investigation",

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Barron, AM, Hojo, Y, Mukai, H, Higo, S, Ooishi, Y, Hatanaka, Y, Ogiue-Ikeda, M, Murakami, G, Kimoto, T, Kawato, S, Hojo, Y, Mukai, H, Kimoto, T, Kawato, S, Hojo, Y, Mukai, H, Murakami, G, Kimoto, T, Kawato, S, Ogiue-Ikeda, M, Kawato, S & Kawato, S 2011, 'Regulation of synaptic plasticity by hippocampus synthesized estradiol', Hormone Molecular Biology and Clinical Investigation, vol. 7, no. 2, pp. 361-375. https://doi.org/10.1515/HMBCI.2011.118

TY - JOUR

T1 - Regulation of synaptic plasticity by hippocampus synthesized estradiol

AU - Barron, Anna M.

AU - Hojo, Yasushi

AU - Mukai, Hideo

AU - Higo, Shimpei

AU - Ooishi, Yuuki

AU - Hatanaka, Yusuke

AU - Ogiue-Ikeda, Mari

AU - Murakami, Gen

AU - Kimoto, Tetsuya

AU - Kawato, Suguru

AU - Hojo, Yasushi

AU - Mukai, Hideo

AU - Kimoto, Tetsuya

AU - Kawato, Suguru

AU - Hojo, Yasushi

AU - Mukai, Hideo

AU - Murakami, Gen

AU - Kimoto, Tetsuya

AU - Kawato, Suguru

AU - Ogiue-Ikeda, Mari

AU - Kawato, Suguru

PY - 2011

Y1 - 2011

N2 - Estradiol is synthesized from cholesterol in hippocampal neurons of adult rats by cytochrome P450 and hydroxyste-roid dehydrogenase enzymes. These enzymes are expressed in the glutamatergic neurons of the hippocampus. Surprisingly., the concentration of estradiol and androgen in the hippocampus is significantly higher than that in circulation. Locally synthesized estradiol rapidly and potently modulates synaptic plasticity within the hippocampus. E2 rapidly potentiates long-term depression and induces spinogenesis through synaptic estrogen receptors and kinases. The rapid effects of estradiol are followed by slow genomic effects mediated by both estrogen receptors located at the synapse and nucleus., modulating long-term potentiation and promoting the formation of new functional synaptic contacts. Age-related changes in hippocampally derived estradiol synthesis and distribution of estrogen receptors may alter synaptic plasticity., and could potentially contribute to age-related cognitive decline. Understanding factors which regulate hippocampal estradiol synthesis could lead to the identification of alternatives to conventional hormone therapy to protect against age-related cognitive decline.

AB - Estradiol is synthesized from cholesterol in hippocampal neurons of adult rats by cytochrome P450 and hydroxyste-roid dehydrogenase enzymes. These enzymes are expressed in the glutamatergic neurons of the hippocampus. Surprisingly., the concentration of estradiol and androgen in the hippocampus is significantly higher than that in circulation. Locally synthesized estradiol rapidly and potently modulates synaptic plasticity within the hippocampus. E2 rapidly potentiates long-term depression and induces spinogenesis through synaptic estrogen receptors and kinases. The rapid effects of estradiol are followed by slow genomic effects mediated by both estrogen receptors located at the synapse and nucleus., modulating long-term potentiation and promoting the formation of new functional synaptic contacts. Age-related changes in hippocampally derived estradiol synthesis and distribution of estrogen receptors may alter synaptic plasticity., and could potentially contribute to age-related cognitive decline. Understanding factors which regulate hippocampal estradiol synthesis could lead to the identification of alternatives to conventional hormone therapy to protect against age-related cognitive decline.

KW - aging

KW - estradiol

KW - estrogen receptor

KW - hippocampus

KW - hormone therapy

KW - long-term depression

KW - long-term potentiation

KW - neurosteroid

KW - selective estrogen receptor modulator

KW - spine

KW - synaptic plasticity

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U2 - 10.1515/HMBCI.2011.118

DO - 10.1515/HMBCI.2011.118

M3 - Article

AN - SCOPUS:85021055324

SN - 1868-1883

VL - 7

SP - 361

EP - 375

JO - Hormone Molecular Biology and Clinical Investigation

JF - Hormone Molecular Biology and Clinical Investigation

IS - 2

ER -

Regulation of synaptic plasticity by hippocampus synthesized estradiol

Abstract

ASJC Scopus Subject Areas

Keywords

UN SDGs

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