Abstract
In this chapter, a post-polymerization double-modification strategy involving sequential thiol-epoxy and esterification reactions is discussed for the preparation of bifunctionalized homopolymer sequences. For this, initially, the synthesis and stability of poly(glycidyl methacrylate), the primary reactive scaffold, are considered. Double modification of the glycidyl units through consecutive thiol-epoxy and esterification reactions is then examined along with its potential to give rise to functionalized molecular bottlebrushes. Finally, application of this strategy for the preparation of amphipathic homopolymer sequences and their application in the arena of siRNA delivery are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 87-104 |
| Number of pages | 18 |
| Journal | Advances in Polymer Science |
| Volume | 269 |
| DOIs | |
| Publication status | Published - 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© Springer International Publishing Switzerland
ASJC Scopus Subject Areas
- General Chemical Engineering
- Organic Chemistry
- Polymers and Plastics
Keywords
- Amphipathic polymers
- Bifunctionalized homopolymers
- Dual-functional polymers Poly(glycidyl methacrylate) Post-polymerization modification Sequential reactions siRNA delivery Thiol-epoxy reaction