Chew Sing Yian

2025

Additive manufacturing in spatial patterning for spinal cord injury treatment

Kwokdinata, C. & Chew, S. Y., Mar 2025, In: Advanced Drug Delivery Reviews. 218, 115523.

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Bioprinted Microchannel Scaffolds Modulate Neuronal Differentiation of Encapsulated Human Spinal Cord Progenitor Cells

Kwokdinata, C., Chai, K., Lau, K., Tan, J. & Chew, S. Y., 2025, (Accepted/In press) In: ACS Applied Bio Materials.

Research output: Contribution to journal › Article › peer-review

Breathing Laser-Spectral Mapping of Cavity-Enhanced Redox Reactions with Subcellular Resolution

Zhu, H., Fang, G., Nie, N., Xie, J., Tseng, P. H., Xiong, Z., Jiang, D., Mao, C. J., Zhu, J. J., Chew, S. Y. & Chen, Y. C., 2025, (Accepted/In press) In: ACS Nano.

Research output: Contribution to journal › Article › peer-review

Open Access

Breathing Laser-Spectral Mapping of Cavity-Enhanced Redox Reactions with Subcellular Resolution

Zhu, H., Fang, G., Nie, N., Xie, J., Tseng, P. H., Xiong, Z., Jiang, D., Mao, C. J., Zhu, J. J., Chew, S. Y. & Chen, Y. C., Mar 25 2025, In: ACS Nano. 19, 11, p. 10955-10965 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Label-Free and High-Throughput Removal of Residual Undifferentiated Cells From iPSC-Derived Spinal Cord Progenitor Cells

Nguyen, T. D., Chooi, W. H., Jeon, H., Chen, J., Tan, J., Roxby, D. N., Lee, C. Y. P., Ng, S. Y., Chew, S. Y. & Han, J., Apr 2024, In: Stem cells translational medicine. 13, 4, p. 387-398 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Label-Free Impedance Analysis of Induced Pluripotent Stem Cell-Derived Spinal Cord Progenitor Cells for Rapid Safety and Efficacy Profiling

He, L., Tan, J., Ng, S. Y., Li, K. H. H., Han, J., Chew, S. Y. & Hou, H. W., 2024, (Accepted/In press) In: Advanced Materials Technologies.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Nontoxic, Biodegradable Hyperbranched Poly(β-amino ester)s for Efficient siRNA Delivery and Gene Silencing

Ooi, Y. J., Huang, C., Lau, K., Chew, S. Y., Park, J. G. & Chan-Park, M. B., Mar 20 2024, In: ACS Applied Materials and Interfaces. 16, 11, p. 14093-14112 20 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

Liu, X., Xin, D. E., Zhong, X., Zhao, C., Li, Z., Zhang, L., Dourson, A. J., Lee, L., Mishra, S., Bayat, A. E., Nicholson, E., Seibel, W. L., Yan, B., Mason, J., Turner, B. J., Gonsalvez, D. G., Ong, W., Chew, S. Y., Ghosh, B. & Yoon, S. O. & 14 others, Xin, M., He, Z., Tchieu, J., Wegner, M., Nave, K. A., Franklin, R. J. M., Dutta, R., Trapp, B. D., Hu, M., Smith, M. A., Jankowski, M. P., Barton, S. K., He, X. & Lu, Q. R., May 9 2024, In: Cell. 187, 10, p. 2465-2484.e22

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells

Tan, J., Chen, J., Roxby, D., Chooi, W. H., Nguyen, T. D., Ng, S. Y., Han, J. & Chew, S. Y., Dec 2024, In: Stem Cell Research and Therapy. 15, 1, 465.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment

Kwokdinata, C., Ramanujam, V., Chen, J., de Oliveira, P. N., Nai, M. H., Chooi, W. H., Lim, C. T., Ng, S. Y., David, L. & Chew, S. Y., Nov 8 2023, In: ACS Applied Materials and Interfaces. 15, 44, p. 50679-50692 14 p.

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Exploiting Caustics for Snapshot 3D Fluorescence Imaging in Wide-field Microscopy

Kumar, S., Li, Z., Huang, C., Lin, V., Chew, S. Y. & Ram, R. J., 2023.

Research output: Contribution to conference › Paper › peer-review

Forum on Materials and Interfaces in Regenerative Medicine

Le Visage, C. & Chew, S. Y., Nov 8 2023, In: ACS Applied Materials and Interfaces. 15, 44, p. 50547-50548 2 p.

Research output: Contribution to journal › Editorial › peer-review

1 Citation (Scopus)

Modulating neuroinflammation through molecular, cellular and biomaterial-based approaches to treat spinal cord injury

Lee, C. Y. P., Chooi, W. H., Ng, S. Y. & Chew, S. Y., Mar 2023, In: Bioengineering and Translational Medicine. 8, 2, e10389.

Research output: Contribution to journal › Review article › peer-review

Open Access

18 Citations (Scopus)

Neural cell membrane-coated DNA nanogels as a potential target-specific drug delivery tool for the central nervous system

Lin, P. H., Huang, C., Hu, Y., Ramanujam, V. S., Lee, E. S., Singh, R., Milbreta, U., Cheung, C., Ying, J. Y. & Chew, S. Y., Nov 2023, In: Biomaterials. 302, 122325.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Reactive oxygen species-responsive clicked assembly of gold nanoparticles to enhance photothermal therapy

Bui, H. T. D., Park, Y., Jung, Y. M., Chew, S. Y. & Yoo, H. S., Jun 15 2023, In: Journal of Materials Chemistry B. 11, 29, p. 6961-6974 14 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury

Chin, J. S., Milbreta, U., Becker, D. L. & Chew, S. Y., Jan 1 2023, In: Journal of Tissue Engineering. 14

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

2022

Bio-Mimicking Acellular Wet Electrospun Scaffolds Promote Accelerated Integration and Re-Epithelialization of Full-Thickness Dermal Wounds

Chin, J. S., Madden, L. E., Phillips, A. R. J., Chew, S. Y. & Becker, D. L., Jul 2022, In: Bioengineering. 9, 7, 324.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Cellular Features Revealed by Transverse Laser Modes in Frequency Domain

Qiao, Z., Xu, H., Zhang, N., Gong, X., Gong, C., Yang, G., Chew, S. Y., Huang, C. & Chen, Y. C., Jan 5 2022, In: Advanced Science. 9, 1, 2103550.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Correction to: Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration (Advanced Science, (2019), 6, 9, (1800808), 10.1002/advs.201800808)

Zhang, N., Milbreta, U., Chin, J. S., Pinese, C., Lin, J., Shirahama, H., Jiang, W., Liu, H., Mi, R., Hoke, A., Wu, W. & Chew, S. Y., May 16 2022, In: Advanced Science. 9, 14, 2201954.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

1 Citation (Scopus)

Delivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crush

Zhang, N., Lin, J., Chin, J. S., Wiraja, C., Xu, C., McGrouther, D. A. & Chew, S. Y., Apr 2022, In: Journal of Tissue Engineering. 13

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

2021

A 3D Fiber-Hydrogel Based Non-Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury

Zhang, N., Lin, J., Lin, V. P. H., Milbreta, U., Chin, J. S., Chew, E. G. Y., Lian, M. M., Foo, J. N., Zhang, K., Wu, W. & Chew, S. Y., Aug 4 2021, In: Advanced Science. 8, 15, 2100805.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Citations (Scopus)

Brain Cell Laser Powered by Deep-Learning-Enhanced Laser Modes

Qiao, Z., Sun, W., Zhang, N., Ang, R., Wang, W., Chew, S. Y. & Chen, Y. C., Nov 18 2021, In: Advanced Optical Materials. 9, 22, 2101421.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Cell Membrane-Coated Electrospun Fibers Enhance Keratinocyte Growth through Cell-Type Specific Interactions

Chooi, W. H., Dong, Q., Low, J. Z. Y., Yuen, C., Chin, J. S., Lin, J., Ong, W., Liu, Q. & Chew, S. Y., May 17 2021, In: ACS Applied Bio Materials. 4, 5, p. 4079-4083 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Injectable hydrogels in stroke and spinal cord injury treatment: A review on hydrogel materials, cell-matrix interactions and glial involvement

Lin, P. H., Dong, Q. & Chew, S. Y., Apr 21 2021, In: Materials Advances. 2, 8, p. 2561-2583 23 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

34 Citations (Scopus)

Mechanotransduction assays for neural regeneration strategies: A focus on glial cells

Marinval, N. & Chew, S. Y., Jun 1 2021, In: APL Bioengineering. 5, 2, 037814.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Citations (Scopus)

Neural Cell Membrane-Coated Nanoparticles for Targeted and Enhanced Uptake by Central Nervous System Cells

Zhang, N., Lin, J. & Chew, S. Y., Dec 1 2021, In: ACS Applied Materials and Interfaces. 13, 47, p. 55840-55850 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Citations (Scopus)

Oriented and sustained protein expression on biomimicking electrospun fibers for evaluating functionality of cells

Lin, J., Chooi, W. H., Ong, W., Zhang, N., Bechler, M. E., ffrench-Constant, C. & Chew, S. Y., Jan 2021, In: Materials Science and Engineering C. 118, 111407.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Phase learning to extract phase from Forelimb(s) and Hindlimb(s) Movement in Real Time

Anopas, D., Lin, J., Wee, S. K., Er Tow, P., Chew, S. Y. & Tech Ang, W., May 19 2021, ECTI-CON 2021 - 2021 18th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology: Smart Electrical System and Technology, Proceedings. Kumsuwan, Y. (ed.). Institute of Electrical and Electronics Engineers Inc., p. 662-665 4 p. 9454920. (ECTI-CON 2021 - 2021 18th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology: Smart Electrical System and Technology, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Rac1-GTPase regulates compression-induced actin protrusions (CAPs) of mesenchymal stem cells in 3D collagen micro-tissues

Lim Lam, V. K., Hin Wong, J. Y., Chew, S. Y. & Chan, B. P., Jul 2021, In: Biomaterials. 274, 120829.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Rehabilitation robotic system with forelimb-hindlimb phase synchronization in rats with spinal cord injury

Anopas, D., Lin, J., Wee, S. K., Er Tow, P., Chew, S. Y. & Tech Ang, W., May 19 2021, ECTI-CON 2021 - 2021 18th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology: Smart Electrical System and Technology, Proceedings. Kumsuwan, Y. (ed.). Institute of Electrical and Electronics Engineers Inc., p. 1125-1128 4 p. 9454866. (ECTI-CON 2021 - 2021 18th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology: Smart Electrical System and Technology, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Scaffold-Based Delivery of CRISPR/Cas9 Ribonucleoproteins for Genome Editing

Chooi, W. H., Chin, J. S. & Chew, S. Y., 2021, Methods in Molecular Biology. Humana Press Inc., p. 183-191 9 p. (Methods in Molecular Biology; vol. 2211).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

2020

A laser microdissection-based axotomy model incorporating the use of biomimicking fiber scaffolds reveals that microRNAs promote axon regeneration over long injury distances

Zhang, N., Lin, J., Chin, J. S., Zhang, K. & Chew, S. Y., Nov 21 2020, In: Biomaterials Science. 8, 22, p. 6286-6300 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Biofunctional scaffolds with high packing density of aligned electrospun fibers support neural regeneration

Cnops, V., Chin, J. S., Milbreta, U. & Chew, S. Y., Dec 1 2020, In: Journal of Biomedical Materials Research - Part A. 108, 12, p. 2473-2483 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP-Dependent Regulation

Ong, W., Marinval, N., Lin, J., Nai, M. H., Chong, Y. S., Pinese, C., Sajikumar, S., Lim, C. T., Ffrench-Constant, C., Bechler, M. E. & Chew, S. Y., Sept 1 2020, In: Small. 16, 37, 2003656.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Citations (Scopus)

Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects

Deng, S., Li, X., Liu, S., Chen, J., Li, M., Chew, S. Y., Leong, K. W. & Cheng, D., Jul 2020, In: Science advances. 6, 29, eabb4005.

Research output: Contribution to journal › Article › peer-review

Open Access

132 Citations (Scopus)

Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions

Nguyen, L., Ong, W., Wang, K., Wang, M., Nizetic, D. & Chew, S., Apr 1 2020, In: Neural Regeneration Research. 15, 4, p. 739-747 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering

Zhang, K., Chooi, W. H., Liu, S., Chin, J. S., Murray, A., Nizetic, D., Cheng, D. & Chew, S. Y., Oct 2020, In: Biomaterials. 256, 120225.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Citations (Scopus)

Modulating Macrophage Phenotype by Sustained MicroRNA Delivery Improves Host-Implant Integration

Lin, J., Mohamed, I., Lin, P. H., Shirahama, H., Milbreta, U., Sieow, J. L., Peng, Y., Bugiani, M., Wong, S. C., Levinson, H. & Chew, S. Y., Feb 1 2020, In: Advanced healthcare materials. 9, 3, 1901257.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

RNA interference in glial cells for nerve injury treatment

Lin, J., Jo, S. B., Kim, T. H., Kim, H. W. & Chew, S. Y., 2020, In: Journal of Tissue Engineering. 11

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Citations (Scopus)

2019

Automatic Inference of Rat's Hindlimb Trajectory to Synchronize with Forelimb Gait Through Phase

Anopas, D., Jatesiktat, P., Lim, G. M., Junquan, L., Wee, S. K., Er Tow, P., Chew, S. Y. & Ang, W. T., Jul 2019, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., p. 4615-4618 4 p. 8857411. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration

Zhang, N., Milbreta, U., Chin, J. S., Pinese, C., Lin, J., Shirahama, H., Jiang, W., Liu, H., Mi, R., Hoke, A., Wu, W. & Chew, S. Y., May 3 2019, In: Advanced Science. 6, 9, 1800808.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Citations (Scopus)

Correction: Scaffold mediated gene knockdown for neuronal differentiation of human neural progenitor cells (Biomaterials Science (2018) 6 (3019-3029) DOI: 10.1039/c8bm01034j)

Chooi, W. H., Ong, W., Murray, A., Lin, J., Nizetic, D. & Chew, S. Y., Jun 2019, In: Biomaterials Science. 7, 6, p. 2623 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Development of a novel force sensing system to measure the ground reaction force of rats with complete spinal cord injury

Anopas, D., Junquan, L., Kiat, S. E., Wee, S. K., Tow, P. E., Chew, S. Y. & Tech, A. W., May 2019, 2019 International Conference on Robotics and Automation, ICRA 2019. Institute of Electrical and Electronics Engineers Inc., p. 877-882 6 p. 8794368. (Proceedings - IEEE International Conference on Robotics and Automation; vol. 2019-May).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Drug therapies and delivery mechanisms to treat perturbed skin wound healing

Chin, J. S., Madden, L., Chew, S. Y. & Becker, D. L., Sept 1 2019, In: Advanced Drug Delivery Reviews. 149-150, p. 2-18 17 p.

Research output: Contribution to journal › Review article › peer-review

162 Citations (Scopus)

In vitro and in vivo evaluation of an electrospun-aligned microfibrous implant for Annulus fibrosus repair

Gluais, M., Clouet, J., Fusellier, M., Decante, C., Moraru, C., Dutilleul, M., Veziers, J., Lesoeur, J., Dumas, D., Abadie, J., Hamel, A., Bord, E., Chew, S. Y., Guicheux, J. & Le Visage, C., Jun 2019, In: Biomaterials. 205, p. 81-93 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Citations (Scopus)

Localised non-viral delivery of nucleic acids for nerve regeneration in injured nervous systems

Zhang, N., Chin, J. S. & Chew, S. Y., Sept 2019, In: Experimental Neurology. 319, 112820.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Citations (Scopus)

Modulation of cell-cell interactions for neural tissue engineering: Potential therapeutic applications of cell adhesion molecules in nerve regeneration

Chooi, W. H. & Chew, S. Y., Mar 2019, In: Biomaterials. 197, p. 327-344 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

50 Citations (Scopus)

Regenerative rehabilitation: Exploring the synergistic effects of rehabilitation and implantation of a bio-functional scaffold in enhancing nerve regeneration

Lin, J., Anopas, D., Milbreta, U., Lin, P. H., Chin, J. S., Zhang, N., Wee, S. K., Tow, A., Ang, W. T. & Chew, S. Y., Dec 2019, In: Biomaterials Science. 7, 12, p. 5150-5160 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing

Chin, J. S., Chooi, W. H., Wang, H., Ong, W., Leong, K. W. & Chew, S. Y., May 2019, In: Acta Biomaterialia. 90, p. 60-70 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries

Ong, W., Pinese, C. & Chew, S. Y., Sept 1 2019, In: Advanced Drug Delivery Reviews. 149-150, p. 19-48 30 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

36 Citations (Scopus)

Chew Sing Yian

Research output

Search results